CHAOTIC MIXING OF MAGNETIC BEADS IN MICRO CELL SEPARATOR
CHAOTIC MIXING OF MAGNETIC BEADS IN MICRO CELL SEPARATOR
复制标题
微量细胞分离器中磁珠的混沌混合
DOI：
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复制
发表时间：
2003
期刊：
影响因子：
--
通讯作者：
Chih
中科院分区：
文献类型：
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作者：
Hiroaki Suzuki;N. Kasagi;Chih
在微尺度生物测定系统中，由于生物分子的扩散系数小，其混合成为关键问题。采用数值模拟的方法，对Suzuki和Ho（2002）设计的一种用于磁珠细胞分离系统的新型微混合器的混沌特性进行了详细的研究。阐明了诱导磁珠运动混沌的机理和最佳条件。结果发现，混沌混合将显着促进附着到生物分子上的磁珠，这实际上不会发生没有外部扰动。主动式微混合器即使在蠕动流状态下也能实现快速有效的混合，而被动式微混合器则无法实现。
In micro-scale biological assay systems, the mixing of biomolecules becomes a critical issue because of their small diffusivity. Chaotic features in a novel micro-mixer designed for cell separation system based on magnetic beads (Suzuki and Ho, 2002) is investigated in detail by means of numerical simulation. The mechanism and the optimum condition to lead the motion of magnetic beads to chaos are clarified. It is found that the chaotic mixing would significantly facilitate the attachment of magnetic beads onto bio-molecules, which practically do not occur without an external perturbation. Active micro-mixers achieve rapid and efficient mixing even in the creeping flow regime, which is not accomplished with the passive micro-mixers.
影响因子：
56.9
作者：
Burns, MA;Johnson, BN;Burke, DT
通讯作者：
Burke, DT