Gene Ontology and the annotation of pathogen genomes: the case of Candida albicans.
Gene Ontology and the annotation of pathogen genomes: the case of Candida albicans.
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DOI：
10.1016/j.tim.2009.04.007
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发表时间：
2009-07
影响因子：
15.9
通讯作者：
Sherlock G
中科院分区：
文献类型：
--
作者：
Arnaud MB;Costanzo MC;Shah P;Skrzypek MS;Sherlock G
基因本体（GO）是一种结构化的受控词汇，用于以一致的方式描述基因产物的作用和位置，这种方式可以在生物体中共享。单细胞真菌白色念珠菌在许多方面与模式生物酿酒酵母相似，但作为人类的病原体和病原体，其生活方式差异很大。随着免疫抑制患者的高危人群不断扩大，侵入性医疗程序的使用增加，耐药性的流行增加，以及其他念珠菌属作为严重病原体的出现，提高我们对念珠菌生物学的理解以指导更好的治疗方法的发展从未如此重要。在这篇简短的综述中，我们考察了GO在C.白念珠菌的基因产物，重点是那些参与发病机制。我们还讨论了如何与GO相结合的序列信息促进知识在相关物种之间的转移，以及这种方法所带来的挑战和机遇。
The Gene Ontology (GO) is a structured controlled vocabulary developed to describe the roles and locations of gene products in a consistent fashion, in a way that can be shared across organisms. The unicellular fungus Candida albicans is similar in many ways to the model organism Saccharomyces cerevisiae, but as both a commensal and a pathogen of humans, differs greatly in its lifestyle. With an expanding at-risk population of immunosuppressed patients, increased use of invasive medical procedures, the increasing prevalence of drug resistance, and the emergence of additional Candida species as serious pathogens, it has never been more critical to improve our understanding of Candida biology to guide the development of better treatments. In this brief review, we examine the importance of GO in the annotation of C. albicans gene products, with a focus on those involved in pathogenesis. We also discuss how sequence information combined with GO facilitates the transfer of knowledge across related species, and the challenges and opportunities that such an approach presents.
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影响因子：
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作者：
Baek, Yong-Un;Li, Mingchun;Davis, Dana A.
通讯作者：
Davis, Dana A.
影响因子：
2.8
作者：
Knight, SAB;Lesuisse, E;Dancis, A
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通讯作者：
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作者：
Bennett, RJ;Johnson, AD
通讯作者：
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