The Effects of Antipsychotic Treatment on Presynaptic Dopamine Synthesis Capacity in First-Episode Psychosis: A Positron Emission Tomography Study.
The Effects of Antipsychotic Treatment on Presynaptic Dopamine Synthesis Capacity in First-Episode Psychosis: A Positron Emission Tomography Study.
复制标题
抗精神病药物对第一期精神病中突触前多巴胺合成能力的影响：一项正电子发射断层扫描研究。
DOI：
10.1016/j.biopsych.2018.07.003
复制
发表时间：
2019-01-01
影响因子：
10.6
通讯作者：
Howes OD
中科院分区：
文献类型：
--
作者：
Jauhar S;Veronese M;Nour MM;Rogdaki M;Hathway P;Natesan S;Turkheimer F;Stone J;Egerton A;McGuire P;Kapur S;Howes OD
纹状体多巴胺合成能力升高与精神病的病因学和抗精神病药物反应有关。抗精神病药物对多巴胺合成能力的影响知之甚少，也没有前瞻性研究在单独的首发精神病样本中研究这个问题。此外，尚不清楚抗精神病药物的疗效是否与多巴胺合成能力的降低有关。我们在首次发作精神病并开始接受抗精神病药物治疗的抗精神病药物初治/未使用抗精神病药物的患者中进行了一项前瞻性[18F]-二羟苯基-L-丙氨酸正电子发射断层扫描研究。多巴胺合成能力（指数为流入率常数）和临床症状（使用阳性和阴性综合征量表测量）在抗精神病药物治疗前和治疗后至少5周的首发精神病患者。来自先前研究的数据表明，13个样本大小将具有>80%的功效来检测α = 0.05（双尾）时多巴胺合成能力的统计学显著变化。共有20人参加了这项研究，其中17人与治疗剂量的抗精神病药物一致。治疗对整个纹状体（p = 0.47）、丘脑或中脑的多巴胺合成能力没有显著影响，多巴胺合成能力的变化与阳性（p = 0.35，p = 0.13）、阴性或总精神病性症状的变化之间也没有任何显著关系。抗精神病药物治疗不会改变多巴胺的合成能力，并且治疗效果不是由多巴胺能功能这方面的变化介导的。
Elevated striatal dopamine synthesis capacity has been implicated in the etiology and antipsychotic response in psychotic illness. The effects of antipsychotic medication on dopamine synthesis capacity are poorly understood, and no prospective studies have examined this question in a solely first-episode psychosis sample. Furthermore, it is unknown whether antipsychotic efficacy is linked to reductions in dopamine synthesis capacity. We conducted a prospective [18F]-dihydroxyphenyl-L-alanine positron emission tomography study in antipsychotic naïve/free people with first-episode psychosis commencing antipsychotic treatment. Dopamine synthesis capacity (indexed as influx rate constant) and clinical symptoms (measured using Positive and Negative Syndrome Scale) were measured before and after at least 5 weeks of antipsychotic treatment in people with first-episode psychosis. Data from a prior study indicated that a sample size of 13 would have >80% power to detect a statistically significant change in dopamine synthesis capacity at alpha = .05 (two tailed). A total of 20 people took part in the study, 17 of whom were concordant with antipsychotic medication at therapeutic doses. There was no significant effect of treatment on dopamine synthesis capacity in the whole striatum (p = .47), thalamus, or midbrain, nor was there any significant relationship between change in dopamine synthesis capacity and change in positive (ρ = .35, p = .13), negative, or total psychotic symptoms. Dopamine synthesis capacity is unaltered by antipsychotic treatment, and therapeutic effects are not mediated by changes in this aspect of dopaminergic function.
登录
查看更多内容
影响因子：
5.3
作者：
Ito, Hiroshi;Takano, Harumasa;Suhara, Tetsuya
通讯作者：
Suhara, Tetsuya
影响因子：
--
作者：
Howes, Oliver D.;Montgomery, Andrew J.;Grasby, Paul M.
通讯作者：
Grasby, Paul M.
DOI：
10.1017/s1461145710001227
发表时间：
2011-04-01
影响因子：
4.8
作者：
Esterlis, Irina;Mitsis, Effie M.;Cosgrove, Kelly P.
通讯作者：
Cosgrove, Kelly P.
影响因子：
10.6
作者：
Andreasen, Nancy C.;Pressler, Marcus;Nopoulos, Peg;Miller, Del;Ho, Beng-Choon
通讯作者：
Ho, Beng-Choon
DOI：
10.1176/appi.ajp.2016.16050503
发表时间：
2017-03-01
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Howes OD;McCutcheon R;Agid O;de Bartolomeis A;van Beveren NJ;Birnbaum ML;Bloomfield MA;Bressan RA;Buchanan RW;Carpenter WT;Castle DJ;Citrome L;Daskalakis ZJ;Davidson M;Drake RJ;Dursun S;Ebdrup BH;Elkis H;Falkai P;Fleischacker WW;Gadelha A;Gaughran F;Glenthøj BY;Graff-Guerrero A;Hallak JE;Honer WG;Kennedy J;Kinon BJ;Lawrie SM;Lee J;Leweke FM;MacCabe JH;McNabb CB;Meltzer H;Möller HJ;Nakajima S;Pantelis C;Reis Marques T;Remington G;Rossell SL;Russell BR;Siu CO;Suzuki T;Sommer IE;Taylor D;Thomas N;Üçok A;Umbricht D;Walters JT;Kane J;Correll CU
通讯作者：
Correll CU