Sexual dimorphism in cancer: insights from transcriptional signatures in kidney tissue and renal cell carcinoma.
Sexual dimorphism in cancer: insights from transcriptional signatures in kidney tissue and renal cell carcinoma.
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癌症中的性别二态性：肾组织和肾细胞癌转录特征的见解。
DOI：
10.1093/hmg/ddab031
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发表时间：
2021-04-27
影响因子：
3.5
通讯作者：
Chanudet E
中科院分区：
文献类型：
--
作者：
Laskar RS;Li P;Ecsedi S;Abedi-Ardekani B;Durand G;Robinot N;Hubert JN;Janout V;Zaridze D;Mukeria A;Mates D;Holcatova I;Foretova L;Swiatkowska B;Dzamic Z;Milosavljevic S;Olaso R;Boland A;Deleuze JF;Muller DC;McKay JD;Brennan P;Le Calvez-Kelm F;Scelo G;Chanudet E
癌症发病率和结果的性别二态性很普遍。了解潜在机制是改善癌症预防和临床管理的基础。肾癌的性别差异尤其显着：在不同人群中，男性的发病率始终呈现出无法解释的两倍增加，且预后较差。我们对 609 个肾肿瘤和 256 个非肿瘤肾组织的全基因组表达和调控网络进行了表征。正常肾脏表现出性别特异性转录特征，包括女性中 X 连锁肿瘤抑制基因的较高表达。性别依赖性基因型-表型关联揭示了女性特异性免疫调节。肿瘤中的性别差异显着扩大，与代谢、男性占优势的非恶性疾病和癌发生有关的关键基因的男性偏向表达，包括肿瘤浸润白细胞的标记物。对性别依赖性肾细胞癌进展和生存的分析发现了与免疫反应和氧稳态有关的预后标志物。总之，人类肾脏组织在分子水平上表现出显着的性别二态性。性别特异性转录特征进一步塑造肾癌，与临床管理相关。
Sexual dimorphism in cancer incidence and outcome is widespread. Understanding the underlying mechanisms is fundamental to improve cancer prevention and clinical management. Sex disparities are particularly striking in kidney cancer: across diverse populations, men consistently show unexplained 2-fold increased incidence and worse prognosis. We have characterized genome-wide expression and regulatory networks of 609 renal tumors and 256 non-tumor renal tissues. Normal kidney displayed sex-specific transcriptional signatures, including higher expression of X-linked tumor suppressor genes in women. Sex-dependent genotype–phenotype associations unraveled women-specific immune regulation. Sex differences were markedly expanded in tumors, with male-biased expression of key genes implicated in metabolism, non-malignant diseases with male predominance and carcinogenesis, including markers of tumor infiltrating leukocytes. Analysis of sex-dependent RCC progression and survival uncovered prognostic markers involved in immune response and oxygen homeostasis. In summary, human kidney tissues display remarkable sexual dimorphism at the molecular level. Sex-specific transcriptional signatures further shape renal cancer, with relevance for clinical management.
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DOI：
10.1093/bioinformatics/btu638
发表时间：
2015-01-15
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Anders S;Pyl PT;Huber W
通讯作者：
Huber W
遗传对人体组织基因表达的影响。
影响因子：
64.8
作者：
GTEx Consortium;Laboratory, Data Analysis &Coordinating Center (LDACC)—Analysis Working Group;Statistical Methods groups—Analysis Working Group;Enhancing GTEx (eGTEx) groups;NIH Common Fund;NIH/NCI;NIH/NHGRI;NIH/NIMH;NIH/NIDA;Biospecimen Collection Source Site—NDRI;Biospecimen Collection Source Site—RPCI;Biospecimen Core Resource—VARI;Brain Bank Repository—University of Miami Brain Endowment Bank;Leidos Biomedical—Project Management;ELSI Study;Genome Browser Data Integration &Visualization—EBI;Genome Browser Data Integration &Visualization—UCSC Genomics Institute, University of California Santa Cruz;Lead analysts:;Laboratory, Data Analysis &Coordinating Center (LDACC):;NIH program management:;Biospecimen collection:;Pathology:;eQTL manuscript working group:;Battle A;Brown CD;Engelhardt BE;Montgomery SB
通讯作者：
Montgomery SB
来自1,092个人基因组的遗传变异的综合图。
影响因子：
64.8
作者：
通讯作者：
--
DOI：
10.1073/pnas.1222435110
发表时间：
2013-02-26
影响因子：
11.1
作者：
Emerling, Brooke M.;Benes, Cyril H.;Cantley, Lewis C.
通讯作者：
Cantley, Lewis C.
影响因子：
15.9
作者：
Gee, Heon Yung;Zhang, Fujian;Hildebrandt, Friedhelm
通讯作者：
Hildebrandt, Friedhelm