Modulation of steady-state auditory evoked potentials by cerebellar rTMS.

Modulation of steady-state auditory evoked potentials by cerebellar rTMS.
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小脑 rTMS 调节稳态听觉诱发电位。

DOI:
10.1007/s00221-006-0588-2
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发表时间:
2006
影响因子:
2
通讯作者:
Pascual-Leone,Alvaro
Pascual-Leone,Alvaro
中科院分区:
医学4区
文献类型:
--
作者:
Pastor,MariaA;Thut,Gregor;Pascual-Leone,Alvaro

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通过脑电(EEG)获得的稳态听觉诱发反应(SSAER)的幅度随小脑听区血流的变化而变化。本研究的目的是探讨小脑在控制SSAER中的作用。为此,我们研究了重复经颅磁刺激(RTMS)引起的小脑半球一过性破坏所引起的SSAERs的变化。在6名健康志愿者的45个头皮电极上记录了伽马频段(32、40和47赫兹)三种不同频率短声序列的SSAER,并与磁刺激前评估的基线SSAER进行了比较。对侧小脑rTMS显著降低了对40赫兹短声反应的稳态反应幅度,并有降低至32赫兹短声反应幅度的趋势。没有观察到47赫兹点击序列的影响,也没有观察到磁刺激听觉刺激同侧小脑或假刺激后的影响。我们的结果表明,rTMS对小脑输出的干扰改变了与皮质听觉处理相关的功能活动。对40赫兹SSAERs的最大效应的发现支持了这样的观点,即小脑是参与调节皮质振荡活动的分布式网络的一部分,并以某种频率特异性地控制听觉驱动的神经元振荡。
Steady-state auditory evoked responses (SSAER) obtained via electroencephalography (EEG) co-vary in amplitude with blood flow changes in the auditory area of the cerebellum. The aim of the present EEG study was to probe the cerebellar role in the control of such SSAER. For this purpose, we investigated changes in SSAERs due to transient disruption of the cerebellar hemisphere by repetitive transcranial magnetic stimulation (rTMS). SSAERs to click-trains of three different frequencies in the gamma-band (32, 40 and 47 Hz) were recorded from 45 scalp electrodes in six healthy volunteers immediately after 1-Hz rTMS and compared to baseline SSAERs assessed prior to magnetic stimulation. Cerebellar rTMS contralateral to the stimulated ear significantly reduced the amplitude of steady-state responses to 40-Hz click-trains and showed a tendency to reduce the amplitude to 32-Hz click-trains. No effects were observed for 47-Hz click-trains, nor for magnetic stimulation of the cerebellum ipsilateral to auditory stimulation or after sham stimulation. Our results suggest that interference with cerebellar output by rTMS modifies functional activity associated with cortical auditory processing. The finding of maximum effects on 40-Hz SSAERs provides support to the notion that the cerebellum is part of a distributed network involved in the regulation of cortical oscillatory activity and points at some frequency-specificity for the control of auditory-driven neuronal oscillations.
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