Silent cerebral infarcts in patients with sickle cell disease: a systematic review and meta-analysis.
Silent cerebral infarcts in patients with sickle cell disease: a systematic review and meta-analysis.
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DOI：
10.1186/s12916-020-01864-8
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发表时间：
2020-12-22
期刊：
影响因子：
9.3
通讯作者：
Cnossen MH
中科院分区：
文献类型：
--
作者：
Houwing ME;Grohssteiner RL;Dremmen MHG;Atiq F;Bramer WM;de Pagter APJ;Zwaan CM;White TJH;Vernooij MW;Cnossen MH
无症状性脑梗死 (SCI) 是镰状细胞病 (SCD) 儿童和成人最常见的神经系统并发症。在这篇系统综述中，我们概述了通过脑磁共振成像 (MRI) 检测 SCD 患者 SCI 的研究。我们关注 SCI 的发生频率、其发展所涉及的危险因素及其临床后果。从开始到 2019 年 6 月 1 日，对 Embase、Ovid 的 MEDLINE ALL、Web of Science Core Collection、Wiley 的 Cochrane Central Register of Trials 和 Google Scholar 的数据库进行了检索。检索产生了 651 项结果，其中 69 项研究符合资格标准。 SCD 患者中 SCI 的患病率为 5.6% 至 80.6%，大多数研究报告的患病率在 20% 至 50% 范围内。 HbSS 和 HbSβ0 SCD 患者中 SCI 的汇总患病率为 29.5%。与其他 SCD 基因型相比，HbSS 和 HbSβ0 基因型患者更容易发生 SCI，因为 9.2% 的 HbSC 和 HbSβ+ 患者出现 SCI。对照受试者的 SCI 平均汇总患病率为 9.8%。纳入研究的数据显示，研究人群平均年龄的增加与平均 SCI 患病率之间存在统计学上显着的关联。 33 项研究探讨了 SCI 的危险因素。大多数危险因素与患病率没有明显的关联，因为或多或少相同数量的研究提供了支持和反对因果关系的证据。本系统回顾和荟萃分析显示 SCI 在 SCD 患者中很常见。没有确定其发展的明确风险因素。需要更大规模、前瞻性和对照的临床、神经心理学和神经影像学研究来了解 SCD 和 SCI 如何影响认知。在线版本包含可在 10.1186/s12916-020-01864-8 获取的补充材料。
Silent cerebral infarcts (SCIs) are the most common neurological complication in children and adults with sickle cell disease (SCD). In this systematic review, we provide an overview of studies that have detected SCIs in patients with SCD by cerebral magnetic resonance imaging (MRI). We focus on the frequency of SCIs, the risk factors involved in their development and their clinical consequences. The databases of Embase, MEDLINE ALL via Ovid, Web of Science Core Collection, Cochrane Central Register of Trials via Wiley and Google Scholar were searched from inception to June 1, 2019. The search yielded 651 results of which 69 studies met the eligibility criteria. The prevalence of SCIs in patients with SCD ranges from 5.6 to 80.6% with most studies reported in the 20 to 50% range. The pooled prevalence of SCIs in HbSS and HbSβ0 SCD patients is 29.5%. SCIs occur more often in patients with the HbSS and HbSβ0 genotype in comparison with other SCD genotypes, as SCIs are found in 9.2% of HbSC and HbSβ+ patients. Control subjects showed a mean pooled prevalence of SCIs of 9.8%. Data from included studies showed a statistically significant association between increasing mean age of the study population and mean SCI prevalence. Thirty-three studies examined the risk factors for SCIs. The majority of the risk factors show no clear association with prevalence, since more or less equal numbers of studies give evidence for and against the causal association. This systematic review and meta-analysis shows SCIs are common in patients with SCD. No clear risk factors for their development were identified. Larger, prospective and controlled clinical, neuropsychological and neuroimaging studies are needed to understand how SCD and SCIs affect cognition. The online version contains supplementary material available at 10.1186/s12916-020-01864-8.
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影响因子：
0.9
作者：
Solomou E;Kraniotis P;Kourakli A;Petsas T
通讯作者：
Petsas T
DOI：
10.4997/jrcpe.2017.313
发表时间：
2017-09-01
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影响因子：
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