Liposome-delivered 131I-labelled Zn(II)-phthalocyanine as a radiodiagnostic agent for tumours.
Liposome-delivered 131I-labelled Zn(II)-phthalocyanine as a radiodiagnostic agent for tumours.
复制标题
脂质体递送 131I 标记的 Zn(II)-酞菁作为肿瘤的放射诊断剂。
DOI：
10.1016/s0304-3835(96)04409-6
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发表时间：
1996
期刊：
影响因子：
9.7
通讯作者：
P. D. De Filippi
中科院分区：
文献类型：
--
作者：
L. Polo;A. Segalla;G. Jori;G. Bocchiotti;G. Verna;R. Franceschini;R. Mosca;P. D. De Filippi
131I-Zn(II)-phthalocyanine (ZnPc) incorporated into unilamellar liposomes has been systemically injected to mice bearing a transplanted MS-2 fibrosarcoma. Biodistribution studies show that the pharmacokinetic behaviour of131I-ZnPc is very similar to that defined for the parent molecule ZnPc including a serum half-life of ca. 12 h, a high recovery from liver and spleen and minimal accumulation in kidney and brain The most important pharmacokinetic parameter is represented by the high tumour/ muscle ratio of131I-ZnPc concentration (ca. 9 at 24 h post-injection). These results suggest the possible use of the radiolabelled derivative for a real-time non-invasive monitoring of the ZnPc concentration in the tumour and peritumoural tissue during photodynamic therapy.
荧光支气管镜检查用于原位癌定位。
影响因子：
3.8
作者：
Profio,AE;Doiron,DR;Balchum,OJ;Huth,GC
通讯作者：
Huth,GC
用血卟啉衍生物检测和定位膀胱原位癌。
DOI：
--
发表时间：
1982
期刊：
Mayo Clinic proceedings. Mayo Clinic
影响因子：
--
作者：
BensonJr,RC;Farrow,GM;Kinsey,JH;Cortese,DA;Zincke,H;Utz,DC
通讯作者：
Utz,DC
氚标记的血卟啉衍生物中放射性污染物的记录。
DOI：
--
发表时间：
1984
期刊：
Progress in clinical and biological research
影响因子：
--
作者：
Gomer,CJ;Little,FM
通讯作者：
Little,FM