Galectin-7 in Epithelial Homeostasis and Carcinomas.
Galectin-7 in Epithelial Homeostasis and Carcinomas.
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DOI：
10.3390/ijms18122760
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发表时间：
2017-12-19
影响因子：
5.6
通讯作者：
Viguier M
中科院分区：
文献类型：
--
作者：
Advedissian T;Deshayes F;Viguier M
凝集素是分布在细胞内外的小的未糖基化的可溶性凝集素。它们共享一个识别碳水化合物（CRD）的保守结构域。尽管半乳糖凝集素对β-半乳糖苷具有共同的亲和力，但它们对复杂聚糖的结合偏好不同。早在20年前，半乳糖凝集素-7就被首次发现，它是一种典型的半乳糖凝集素，具有单个CRD，能够形成二价同型二聚体。这种凝集素主要在层状上皮中表达，在上皮组织中被描述为参与凋亡反应、增殖和分化，但也参与细胞粘附和迁移。凝集素家族的大多数成员都与癌症生物学有关。凝集素在肿瘤中的主要功能之一是其免疫调节潜能和抗血管生成活性。事实上，半乳糖凝集素-1和-3已经成为临床试验的目标。凝集素在肿瘤进展中的另一个相关功能是它们调节细胞迁移和细胞粘附的能力。在这些半乳糖凝集素中，半乳糖凝集素-7在各种癌症中异常表达，最显著的是在癌中，并参与癌症的进展和转移，但其在肿瘤生物学中的确切功能尚不清楚。在这一期中，我们将重点关注半乳糖凝集素-7在上皮细胞中的生理功能，并介绍半乳糖凝集素-7在肿瘤中的表达变化，目的是描述其在肿瘤进展中的可能功能。
Galectins are small unglycosylated soluble lectins distributed both inside and outside the cells. They share a conserved domain for the recognition of carbohydrates (CRD). Although galectins have a common affinity for β-galatosides, they exhibit different binding preferences for complex glycans. First described twenty years ago, galectin-7 is a prototypic galectin, with a single CRD, able to form divalent homodimers. This lectin, which is mainly expressed in stratified epithelia, has been described in epithelial tissues as being involved in apoptotic responses, in proliferation and differentiation but also in cell adhesion and migration. Most members of the galectins family have been associated with cancer biology. One of the main functions of galectins in cancer is their immunomodulating potential and anti-angiogenic activity. Indeed, galectin-1 and -3, are already targeted in clinical trials. Another relevant function of galectins in tumour progression is their ability to regulate cell migration and cell adhesion. Among these galectins, galectin-7 is abnormally expressed in various cancers, most prominently in carcinomas, and is involved in cancer progression and metastasis but its precise functions in tumour biology remain poorly understood. In this issue, we will focus on the physiological functions of galectin-7 in epithelia and present the alterations of galectin-7 expression in carcinomas with the aim to describe its possible functions in tumour progression.
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影响因子：
7.5
作者：
Boscher, Cecile;Dennis, James W.;Nabi, Ivan R.
通讯作者：
Nabi, Ivan R.
影响因子：
11.2
作者：
Demers, Melanie;Biron-Pain, Katherine;St-Pierre, Yves
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DOI：
10.1038/jid.2015.366
发表时间：
2016-01
期刊：
The Journal of investigative dermatology
影响因子：
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作者：
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通讯作者：
Liu FT
影响因子：
2.9
作者：
Di Lella, Santiago;Sundblad, Victoria;Cerliani, Juan P.;Guardia, Carlos M.;Estrin, Dario A.;Vasta, Gerardo R.;Rabinovich, Gabriel A.
通讯作者：
Rabinovich, Gabriel A.
影响因子：
4.7
作者：
Cagnoni AJ;Pérez Sáez JM;Rabinovich GA;Mariño KV
通讯作者：
Mariño KV