MAPK/ERK Signaling Pathway in Hepatocellular Carcinoma.
MAPK/ERK Signaling Pathway in Hepatocellular Carcinoma.
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MAPK/ERK信号通路在肝细胞癌中的作用
DOI：
10.3390/cancers13123026
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发表时间：
2021-06-17
期刊：
影响因子：
5.2
通讯作者：
Ro SW
中科院分区：
文献类型：
--
作者：
Moon H;Ro SW
肝癌是人类最致命的癌症之一，丝裂原活化蛋白激酶/细胞外信号调节激酶（MAPK/ERK）信号通路在肝癌中经常被激活。除了基因突变导致MAPK/ERK信号级联中的效应分子持续激活外，还有MAPK/ERK信号通路在癌症中被激活的其他途径。在这篇综述中，我们将介绍多种调节MAPK/ERK信号通路的调节剂，并考虑靶向效应剂和调节剂以抑制促肿瘤MAPK/ERK信号通路的可能性，特别是在肝癌中。肝细胞癌（HCC）是世界范围内的主要健康问题，其发病率正在稳步上升。近年来，肝癌中的MAPK/ERK信号通路再次受到基础和临床研究人员的关注。MAPK/ERK信号通路在超过50%的人类HCC病例中被激活；然而，在HCC中很少发现RAS和RAF基因的激活突变，这是导致其他癌症中MAPK/ERK信号通路激活的主要遗传事件。这表明在HCC中信号通路的激活背后存在另一种机制。在这里，我们将回顾在理解MAPK/ERK信号通路激活的细胞和分子机制方面的最新进展，并讨论在HCC背景下针对信号通路的潜在治疗策略。
The mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) signaling pathway is frequently activated in liver cancer, which is one of the most lethal cancers in humans. In addition to genetic mutation leading to persistent activation of effector molecules in the MAPK/ERK signaling cascade, there are alternative means by which the MAPK/ERK signaling pathway is activated in cancer. In this review, we will introduce the diverse modulators regulating the MAPK/ERK signaling pathway and consider the possibility of targeting the effectors and regulators in order to suppress the pro-tumorigenic MAPK/ERK signaling pathway, especially in liver cancer. Hepatocellular carcinoma (HCC) is a major health concern worldwide, and its incidence is increasing steadily. Recently, the MAPK/ERK signaling pathway in HCC has gained renewed attention from basic and clinical researchers. The MAPK/ERK signaling pathway is activated in more than 50% of human HCC cases; however, activating mutations in RAS and RAF genes are rarely found in HCC, which are major genetic events leading to the activation of the MAPK/ERK signaling pathway in other cancers. This suggests that there is an alternative mechanism behind the activation of the signaling pathway in HCC. Here, we will review recent advances in understanding the cellular and molecular mechanisms involved in the activation of the MAPK/ERK signaling pathway and discuss potential therapeutic strategies targeting the signaling pathway in the context of HCC.
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影响因子：
2.9
作者：
Bao H;Guo CG;Qiu PC;Zhang XL;Dong Q;Wang YK
通讯作者：
Wang YK
DOI：
10.1073/pnas.0409722102
发表时间：
2005-03-01
影响因子：
11.1
作者：
Campbell, JS;Hughes, SD;Fausto, N
通讯作者：
Fausto, N
影响因子：
1.2
作者：
Cochin, Valerie;Gross-Goupil, Marine;Le Moulec, Sylvestre
通讯作者：
Le Moulec, Sylvestre
K-RAS前化作为潜在的抗癌靶标。
DOI：
10.1007/s10555-020-09902-w
发表时间：
2020-12
期刊：
Cancer metastasis reviews
影响因子：
--
作者：
Baranyi M;Buday L;Hegedűs B
通讯作者：
Hegedűs B
影响因子：
25.7
作者：
Calvisi DF;Ladu S;Conner EA;Seo D;Hsieh JT;Factor VM;Thorgeirsson SS
通讯作者：
Thorgeirsson SS