The human connectome project for disordered emotional states: Protocol and rationale for a research domain criteria study of brain connectivity in young adult anxiety and depression.
The human connectome project for disordered emotional states: Protocol and rationale for a research domain criteria study of brain connectivity in young adult anxiety and depression.
复制标题
DOI：
10.1016/j.neuroimage.2020.116715
复制
发表时间：
2020-07-01
期刊：
影响因子：
5.7
通讯作者：
Williams LM
中科院分区：
文献类型：
--
作者：
Tozzi L;Staveland B;Holt-Gosselin B;Chesnut M;Chang SE;Choi D;Shiner M;Wu H;Lerma-Usabiaga G;Sporns O;Barch DM;Gotlib IH;Hastie TJ;Kerr AB;Poldrack RA;Wandell BA;Wintermark M;Williams LM
通过人类连接组计划（HCP），我们对健康大脑功能性连接组的理解已经大大加快。鉴于迫切的公共卫生需求，我们必须增加我们对连接体功能障碍如何导致精神状态紊乱的理解。由高度负面情绪或失去积极情绪体验引起的精神障碍影响着全球4亿多人。这种情绪障碍的状态跨越了情绪和焦虑障碍的多种诊断类别，并因认知功能的伴随中断而加剧。毫不奇怪，这些形式的精神病理学是全球残疾的主要原因。由NIMH牵头的研究领域标准（RDoC）倡议提供了一个框架，用于表征连接体功能障碍之间的关系，锚定在神经回路和行为和自我报告症状的表型特征中。在这里，我们报告了我们的人类疾病相关的连接体协议，用于将RDoC框架与HCP协议相结合，以表征紊乱情绪状态下的连接体功能障碍，并提供来自代表性参与者样本的质量控制数据。我们专注于三个RDoC域和结构最相关的抑郁和焦虑：1）损失和急性威胁的负价系统（NVS）域; 2）奖励评价和反应的正价系统（PVS）域;和3）工作记忆和认知控制的认知系统（CS）域。对于29名健康对照者，我们提供了初步的成像数据：在静息状态和与我们感兴趣的结构相匹配的任务（“情感”、“赌博”和“连续表现”任务）中收集的功能性磁共振成像，以及弥散加权成像。所有功能扫描均显示出良好的信噪比。建立的神经网络鲁棒性确定在休息状态条件下的独立成分分析。负性情绪面孔的加工显著激活了双侧背外侧前额叶和枕叶皮层、梭状回和杏仁核。奖励在双侧背外侧前额叶、顶叶和枕叶皮质以及纹状体中引起反应。工作记忆与背外侧前额叶、顶叶、运动、颞叶和岛叶皮质、纹状体和小脑的激活有关。弥散纤维束成像显示沿着已知白色束的分数各向异性的一致配置文件。我们还表明，结果与HCP健康青年数据发布的匹配样本中的结果相当。这些初步的数据提供了基础，收购的250名受试者正在经历混乱的情绪状态。完成后，这些数据将用于开发神经生物学模型，将连接体功能障碍映射到特定的行为和症状。
Through the Human Connectome Project (HCP) our understanding of the functional connectome of the healthy brain has been dramatically accelerated. Given the pressing public health need, we must increase our understanding of how connectome dysfunctions give rise to disordered mental states. Mental disorders arising from high levels of negative emotion or from the loss of positive emotional experience affect over 400 million people globally. Such states of disordered emotion cut across multiple diagnostic categories of mood and anxiety disorders and are compounded by accompanying disruptions in cognitive function. Not surprisingly, these forms of psychopathology are the leading cause of disability worldwide. The Research Domain Criteria (RDoC) initiative spearheaded by NIMH offers a framework for characterizing the relations among connectome dysfunctions, anchored in neural circuits and phenotypic profiles of behavior and self-reported symptoms. Here, we report on our Connectomes Related to Human Disease protocol for integrating an RDoC framework with HCP protocols to characterize connectome dysfunctions in disordered emotional states, and present quality control data from a representative sample of participants. We focus on three RDoC domains and constructs most relevant to depression and anxiety: 1) loss and acute threat within the Negative Valence System (NVS) domain; 2) reward valuation and responsiveness within the Positive Valence System (PVS) domain; and 3) working memory and cognitive control within the Cognitive System (CS) domain. For 29 healthy controls, we present preliminary imaging data: functional magnetic resonance imaging collected in the resting state and in tasks matching our constructs of interest (“Emotion”, “Gambling” and “Continuous Performance” tasks), as well as diffusion-weighted imaging. All functional scans demonstrated good signal-to-noise ratio. Established neural networks were robustly identified in the resting state condition by independent component analysis. Processing of negative emotional faces significantly activated the bilateral dorsolateral prefrontal and occipital cortices, fusiform gyrus and amygdalae. Reward elicited a response in the bilateral dorsolateral prefrontal, parietal and occipital cortices, and in the striatum. Working memory was associated with activation in the dorsolateral prefrontal, parietal, motor, temporal and insular cortices, in the striatum and cerebellum. Diffusion tractography showed consistent profiles of fractional anisotropy along known white matter tracts. We also show that results are comparable to those in a matched sample from the HCP Healthy Young Adult data release. These preliminary data provide the foundation for acquisition of 250 subjects who are experiencing disordered emotional states. When complete, these data will be used to develop a neurobiological model that maps connectome dysfunctions to specific behaviors and symptoms.
登录
查看更多内容
DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
2.9
作者：
Fales, C. L.;Barch, D. M.;Braver, T. S.
通讯作者：
Braver, T. S.
影响因子：
6.9
作者：
Elliott, R;Baker, SC;Sahakian, BJ
通讯作者：
Sahakian, BJ
影响因子：
6.6
作者：
Ahmed AT;Frye MA;Rush AJ;Biernacka JM;Craighead WE;McDonald WM;Bobo WV;Riva-Posse P;Tye SJ;Mayberg HS;Hall-Flavin DK;Skime MK;Jenkins GD;Wang L;Krishnan RR;Weinshilboum RM;Kaddurah-Daouk R;Dunlop BW;Mood Disorders Precision Medicine Consortium (MDPMC)
通讯作者：
Mood Disorders Precision Medicine Consortium (MDPMC)
影响因子：
3.6
作者：
Burckhardt, Carol S;Anderson, Kathryn L
通讯作者：
Anderson, Kathryn L