Deconvolution of serum cortisol levels by using compressed sensing.
Deconvolution of serum cortisol levels by using compressed sensing.
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DOI：
10.1371/journal.pone.0085204
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Brown EN
中科院分区：
文献类型：
--
作者：
Faghih RT;Dahleh MA;Adler GK;Klerman EB;Brown EN
皮质醇从肾上腺的脉冲式释放是由一个分级系统控制的，该系统涉及来自下丘脑的促肾上腺皮质激素释放激素（CRH）、来自垂体的促肾上腺皮质激素（ACTH）和来自肾上腺的皮质醇。确定皮质醇分泌事件的数量，时间和幅度，并从血清皮质醇水平的连续测量中恢复输注和清除率是一个具有挑战性的问题。尽管对这一问题进行了多年的研究，但一直未能找到一个完全令人满意的解决办法。我们将这个问题表述为非凸优化问题，并使用坐标下降算法来解决它，该算法具有以下原则组合：（i）用于恢复分泌事件的幅度和定时的压缩传感，以及（ii）用于选择正则化参数的广义交叉验证。仅使用所观察到的血清皮质醇水平，我们使用二阶线性微分方程模拟肾上腺皮质醇分泌，该方程具有代表响应于ACTH脉冲而释放的皮质醇脉冲的脉动输入。使用我们的算法和假设脉冲数在24小时内介于15到22个脉冲之间，我们成功地对模拟数据集和每10分钟从10名健康女性中采样的实际24小时血清皮质醇数据集进行了去卷积。假设一分钟的决议的分泌事件，我们得到生理上合理的时间和幅度的每个皮质醇分泌事件与R 2以上0.92。脉冲性激素释放的幅度和时间的识别允许（i）朝着理解病理神经内分泌状态的目标量化正常和异常分泌模式，以及（ii）潜在地设计用于治疗激素紊乱的最佳方法。
The pulsatile release of cortisol from the adrenal glands is controlled by a hierarchical system that involves corticotropin releasing hormone (CRH) from the hypothalamus, adrenocorticotropin hormone (ACTH) from the pituitary, and cortisol from the adrenal glands. Determining the number, timing, and amplitude of the cortisol secretory events and recovering the infusion and clearance rates from serial measurements of serum cortisol levels is a challenging problem. Despite many years of work on this problem, a complete satisfactory solution has been elusive. We formulate this question as a non-convex optimization problem, and solve it using a coordinate descent algorithm that has a principled combination of (i) compressed sensing for recovering the amplitude and timing of the secretory events, and (ii) generalized cross validation for choosing the regularization parameter. Using only the observed serum cortisol levels, we model cortisol secretion from the adrenal glands using a second-order linear differential equation with pulsatile inputs that represent cortisol pulses released in response to pulses of ACTH. Using our algorithm and the assumption that the number of pulses is between 15 to 22 pulses over 24 hours, we successfully deconvolve both simulated datasets and actual 24-hr serum cortisol datasets sampled every 10 minutes from 10 healthy women. Assuming a one-minute resolution for the secretory events, we obtain physiologically plausible timings and amplitudes of each cortisol secretory event with R 2 above 0.92. Identification of the amplitude and timing of pulsatile hormone release allows (i) quantifying of normal and abnormal secretion patterns towards the goal of understanding pathological neuroendocrine states, and (ii) potentially designing optimal approaches for treating hormonal disorders.
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影响因子：
2
作者：
Keenan, DM;Chattopadhyay, S;Veldhuis, JD
通讯作者：
Veldhuis, JD
影响因子：
1.8
作者：
Conrad, Matthias;Hubold, Christian;Peters, Achim
通讯作者：
Peters, Achim
影响因子：
5.8
作者：
ROELFSEMA, F;VANDENBERG, G;ETMAN, BHB
通讯作者：
ETMAN, BHB
DOI：
10.1152/ajpendo.00048.2009
发表时间：
2010-02-01
影响因子：
5.1
作者：
Vis, Daniel J.;Westerhuis, Johan A.;Smilde, Age K.
通讯作者：
Smilde, Age K.
影响因子：
2.5
作者：
GOLUB, GH;HEATH, M;WAHBA, G
通讯作者：
WAHBA, G