Prostate Cancer Detection Rate of Freehand versus 3-Dimensional Template Mapping Biopsy Using a Magnetic Resonance Imaging-Ultrasound Fusion Device in Biopsy Naïve Men.
Prostate Cancer Detection Rate of Freehand versus 3-Dimensional Template Mapping Biopsy Using a Magnetic Resonance Imaging-Ultrasound Fusion Device in Biopsy Naïve Men.
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使用磁共振成像超声融合装置对未进行活检的男性进行徒手与 3 维模板映射活检的前列腺癌检出率。
DOI：
10.1097/ju.0000000000000587
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Natarajan,Shyam
中科院分区：
文献类型：
--
作者：
Zhou,SteveR;Chang,Edward;Patankar,Aalhad;Huang,Jiaoti;Marks,LeonardS;Natarajan,Shyam
目的靶向前列腺活检装置包括一个 3 维数字模板网格，用于指导系统活检位置。与传统的徒手活检方法相比，遵循模板可以更好地确保前列腺采样的均匀性和分布均匀性，从而可能减少假阴性活检的机会。因此，我们确定了通过传统徒手系统采样与使用磁共振成像-超声融合装置的模板映射采样获得的癌症检出率。材料和方法根据机构审查委员会批准的方案对接受一线常规或图像引导前列腺活检的男性进行回顾性鉴定。研究中排除了之前接受过活检或治疗或采集少于 10 个核心的男性。通过图像引导活检获得的靶向核心经过分析审查以模拟系统模板活检。将所得癌症检出率与传统活检的结果进行比较。结果我们在 2006 年至 2014 年间确定了 1,582 名符合分析标准的患者，其中 1,052 名接受了传统活检，530 名接受了磁共振成像-超声融合装置的模板活检。两组患者的年龄、前列腺特异性抗原和系统核心数量相同。模板活检在 530 名男性中的 257 名 (48.5%) 中检测出任何前列腺癌，在 196 名 (37.0%) 中检测出临床显着癌症，而传统活检在 1,052 名男性中的 432 名 (41.0%) 中检测出任何癌症 (p=0.005)，在 308 名 (29.2%) 中检测出临床显着癌症 (p=0.002)。结论 模板映射系统活检检测到更多前列腺癌与未接受活检的男性中的传统取样相比。作为一种前期筛查工具，它是磁共振成像-超声融合活检的一种有前途的、具有成本效益的替代方案。
PurposeTargeted prostate biopsy devices include a 3-dimensional digital template grid to guide systematic biopsy locations. Following a template could better ensure uniform and well distributed sampling of the prostate compared to the traditional freehand biopsy approach, possibly decreasing the chance of false-negative biopsy. Thus, we determined cancer detection rates obtained by conventional freehand systematic sampling vs template mapping sampling using a magnetic resonance imaging-ultrasound fusion device.Materials and MethodsMen who underwent first line conventional or image guided prostate biopsy were identified retrospectively in an institutional review board approved protocol. Excluded from study were men with prior biopsy or treatment or fewer than 10 cores taken. Targeted cores obtained by image guided biopsy were censored from analysis to simulate systematic template biopsy. The resulting cancer detection rate was compared to that of conventional biopsy.ResultsWe identified 1,582 patients between 2006 and 2014 who met the criteria for analysis, including 1,052 who underwent conventional biopsy and 530 who underwent template biopsy with a magnetic resonance imaging-ultrasound fusion device. Patient age, prostate specific antigen and the number of systematic cores were the same in the 2 groups. Template biopsy detected any prostate cancer in 257 of 530 men (48.5%) and clinically significant cancer in 196 (37.0%) while conventional biopsy detected any cancer in 432 of 1,052 (41.0%) (p=0.005) and clinically significant cancer in 308 (29.2%) (p=0.002).ConclusionsTemplate mapping systematic biopsy detected more prostate cancer than conventional sampling in biopsy naïve men. It is a promising cost-effective alternative to magnetic resonance imaging-ultrasound fusion biopsy as an upfront screening tool.
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DOI：
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发表时间：
2016-12
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