Co-localization patterns of neurotensin receptor 1 and tyrosine hydroxylase in brain regions involved in motivation and social behavior in male European starlings.
Co-localization patterns of neurotensin receptor 1 and tyrosine hydroxylase in brain regions involved in motivation and social behavior in male European starlings.
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DOI：
10.1016/j.jchemneu.2018.01.002
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发表时间：
2018-04
影响因子：
2.8
通讯作者：
Riters LV
中科院分区：
文献类型：
--
作者：
Merullo DP;Spool JA;Zhao C;Riters LV
动物在不同的社会环境中进行交流，以传达特定于这些环境的信息，例如性动机或竞争动机。在季节性繁殖的雄性鸣禽中，白天长度的季节性变化和睾丸激素的增加刺激了性动机的歌曲，这些歌曲针对雌性求偶和繁殖。多巴胺和睾丸激素可能作用于同一个大脑区域，以刺激性动机的歌唱。作用于神经降压素受体1（NTR 1）的神经肽神经降压素可强烈影响多巴胺传递。本研究的目的是深入了解生理学的季节性变化在多大程度上改变了神经降压素和多巴胺之间的相互作用，以调整上下文适当的通信。男性欧洲椋鸟进行了检查，在生理条件下，刺激季节的典型形式的通信：夏末/初秋非繁殖条件（低睾丸激素，鸟类很少唱歌），晚秋非繁殖条件（低睾丸激素，鸟类产生非性动机的歌曲），和春季繁殖条件（高睾丸激素，男性产生性动机的歌曲）。双荧光免疫标记检测酪氨酸羟化酶（TH;多巴胺合成的限速酶）和NTR 1之间的共定位模式在大脑区域的动机和歌曲的生产（腹侧被盖区，内侧视前核，导水管周围灰质，和外侧隔）。TH和NTR 1之间的共定位存在于腹侧被盖区的所有生理条件下，共定位的细胞的数量没有不同的条件。TH和NTR 1的免疫标记也存在于其他检查区域，虽然没有共定位。这些结果支持的假设，NTR 1和多巴胺之间的相互作用，在腹侧被盖区可能会调节发声，但表明睾酮或光周期引起的NTR 1/TH共定位的变化不根据季节性适当的调整通信。
Animals communicate in distinct social contexts to convey information specific to those contexts, such as sexual or agonistic motivation. In seasonally-breeding male songbirds, seasonal changes in day length and increases in testosterone stimulate sexually-motivated song directed at females for courtship and reproduction. Dopamine and testosterone may act in the same brain regions to stimulate sexually-motivated singing. The neuropeptide neurotensin, acting at the neurotensin receptor 1 (NTR1), can strongly influence dopamine transmission. The goal of this study was to gain insight into the degree to which seasonal changes in physiology modify interactions between neurotensin and dopamine to adjust context-appropriate communication. Male European starlings were examined in physiological conditions that stimulate season-typical forms of communication: late summer/early fall non-breeding condition (low testosterone; birds sing infrequently), late fall non-breeding condition (low testosterone; birds produce non-sexually motivated song), and spring breeding condition (high testosterone; males produce sexually-motivated song). Double fluorescent immunolabeling was performed to detect co-localization patterns between tyrosine hydroxylase (TH; the rate-limiting enzyme in dopamine synthesis) and NTR1 in brain regions implicated in motivation and song production (the ventral tegmental area, medial preoptic nucleus, periaqueductal gray, and lateral septum). Co-localization between TH and NTR1 was present in the ventral tegmental area for all physiological conditions, and the number of co-localized cells did not differ across conditions. Immunolabeling for TH and NTR1 was also present in the other examined regions, although no co-localization was seen. These results support the hypothesis that interactions between NTR1 and dopamine in the ventral tegmental area may modulate vocalizations, but suggest that testosterone- or photoperiod-induced changes in NTR1/TH co-localization do not underlie seasonally-appropriate adjustment of communication.
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DOI：
10.1111/ejn.12871
发表时间：
2015-05
期刊：
The European journal of neuroscience
影响因子：
--
作者：
Brown EC;Steadman CJ;Lee TM;Padmanabhan V;Lehman MN;Coolen LM
通讯作者：
Coolen LM
DOI：
10.1196/annals.1298.043
发表时间：
2004-01-01
期刊：
BEHAVIORAL NEUROBIOLOGY OF BIRDSONG
影响因子：
--
作者：
Ball, GF;Auger, CJ;Balthazart, J
通讯作者：
Balthazart, J
影响因子：
3.5
作者：
BOHNER, J;CHAIKEN, ML;MARLER, P
通讯作者：
MARLER, P
影响因子：
1.7
作者：
Appeltants, D;Ball, GF;Balthazart, J
通讯作者：
Balthazart, J
影响因子：
1.7
作者：
ABSIL, P;BALTHAZART, J
通讯作者：
BALTHAZART, J