Its written all over your face: The molecular and physiological consequences of aging skin.
Its written all over your face: The molecular and physiological consequences of aging skin.
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DOI：
10.1016/j.mad.2020.111315
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发表时间：
2020-09
影响因子：
5.3
通讯作者：
Lowry WE
中科院分区：
文献类型：
--
作者：
Lowry WE
也许组织老化最明显的后果体现在皮肤上。头发变白、脱发、皱纹和老年斑都是生理衰老症状的标志，其中许多与其他组织的过程类似，但结果不太明显。虽然对皮肤衰老的研究已经进行了几十年，但最近的工作已经阐明了皮肤衰老的许多基本分子和生理原因。最近的技术进步已经允许检测和量化导致皮肤老化的各种生理触发因素，分子方法已经开始确定这些表型特征的病因。本文将尝试总结这一领域的最新工作，并对下一波研究提供一些推测。
Perhaps the most recognizable consequences of tissue aging are manifest in the skin. Hair graying and loss, telltale wrinkles, and age spots are indicative of physiological aging symptoms, many of which are analogous to processes in other tissues as well with less visible outcomes. While the study of skin aging has been conducted for decades, more recent work has illuminated many of the fundamental molecular and physiological causes of aging in the skin. Recent technological advances have allowed for the detection and quantification of a variety of physiological triggers that lead to aging in the skin and molecular methods have begun to determine the etiology of these phenotypic features. This review will attempt to summarize recent work in this area and provide some speculation about the next wave of studies.
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DOI：
10.1016/j.jid.2017.01.007
发表时间：
2017-06
期刊：
The Journal of investigative dermatology
影响因子：
--
作者：
Hu L;Mauro TM;Dang E;Man G;Zhang J;Lee D;Wang G;Feingold KR;Elias PM;Man MQ
通讯作者：
Man MQ
影响因子：
21.3
作者：
Flores A;Schell J;Krall AS;Jelinek D;Miranda M;Grigorian M;Braas D;White AC;Zhou JL;Graham NA;Graeber T;Seth P;Evseenko D;Coller HA;Rutter J;Christofk HR;Lowry WE
通讯作者：
Lowry WE
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
64.8
作者：
Chang, Chiung-Ying;Pasolli, H. Amalia;Giannopoulou, Eugenia G.;Guasch, Geraldine;Gronostajski, Richard M.;Elemento, Olivier;Fuchs, Elaine
通讯作者：
Fuchs, Elaine
影响因子：
10.3
作者：
Birch, MP;Messenger, JF;Messenger, AG
通讯作者：
Messenger, AG