Deleterious Effect of Glucose Pretreatment on Recovery from Diffuse Cerebral Ischemia in the Cat: I. Local Cerebral Blood Flow and Glucose Utilization
Deleterious Effect of Glucose Pretreatment on Recovery from Diffuse Cerebral Ischemia in the Cat: I. Local Cerebral Blood Flow and Glucose Utilization
复制标题
葡萄糖预处理对猫弥漫性脑缺血恢复的有害影响：I.局部脑血流量和葡萄糖利用
作者：
M. Ginsberg;F. Welsh;W. Budd
通过基底动脉和双侧颈动脉闭塞和低血压在戊巴比妥麻醉的猫中造成弥漫性脑缺血。局部脑血流量（1CBF）用14 C-安替比林放射自显影，局部脑葡萄糖利用率用14 C-2-脱氧葡萄糖。在没有葡萄糖预处理的动物中，15分钟的缺血导致缺血后脑灌注均匀减少至对照组的31%; 30分钟的缺血在大脑皮层和深灰色结构中产生缺血后灌注异质性。在用葡萄糖预处理的动物中，1.5 gm/kg肾内注射，仅在缺血15分钟后观察到不均匀的脑灌注，并且在30分钟的损伤后发生严重的脑再灌注的全局损伤。在后者动物的脱氧葡萄糖放射自显影显着的完全抑制示踪剂摄取在大脑皮层和一个矛盾的增加示踪剂浓度在大脑白色的问题。给药动物的平均血糖超过1000 mg/100 ml。缺血前的高葡萄糖负荷显著损害缺血后的脑灌注。
Diffuse cerebral ischemia was created in pentobarbital-anesthetized cats by basllar and bilateral carotid artery occlusions and hypotension. Local cerebral blood flow (1CBF) was assessed autoradiographically with 14C-antipyrine, and local cerebral glucose utilization with 14C-2-deoxyglucose. In animals without glucose pretreatment, 15 min of ischemia led to a homogeneous reduction of post-ischemic cerebral perfusion to 31% of control; ischemia of 30 min produced post-ischemic perfusion heterogeneities in the cerebral cortex and deep gray structures. In animals pretreated with dextrose, 1.5 gm/kg intrarenously, heterogeneous cerebral perfusion was observed following only 15 min of ischemia, and a severe global impairment of cerebral reperfusion occurred after the 30 min insult. Deoxyglucose autoradiograms in the latter animals were remarkable for a complete suppression of tracer uptake in the cerebral cortex and a paradoxically increased tracer concentration in the cerebral white matter. Mean plasma glucose in the treated animals exceeded 1000 mg/100 ml. Large glucose loads prior to ischemia dramatically Impair post-ischemic cerebral perfusion.
葡萄糖预处理对猫弥漫性脑缺血恢复的有害影响。
影响因子：
8.3
作者：
Welsh,FA;Ginsberg,MD;Rieder,W;Budd,WW
通讯作者：
Budd,WW