When SUV Matters: FDG PET/CT at Baseline Correlates with Survival in Soft Tissue and Ewing Sarcoma.
When SUV Matters: FDG PET/CT at Baseline Correlates with Survival in Soft Tissue and Ewing Sarcoma.
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DOI：
10.3390/life11090869
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发表时间：
2021-08-24
期刊：
影响因子：
--
通讯作者：
Britschgi C
中科院分区：
文献类型：
--
作者：
Hack RI;Becker AS;Bode-Lesniewska B;Exner GU;Müller DA;Ferraro DA;Warnock GI;Burger IA;Britschgi C
简介：正电子发射断层扫描/计算机断层扫描（PET/CT）在肉瘤管理中的作用和作为预后工具的研究。然而，目前尚不清楚哪个指标最有用。我们旨在研究基于体积的PET指标（肿瘤体积（TV）和总病变糖酵解（TLG））在预测软组织和骨肉瘤患者生存率方面是否上级最大标准化摄取值（SUVmax）和其他指标。材料与方法：在这项回顾性队列研究中，我们筛选了超过52000例PET/CT扫描，以识别诊断为软组织、骨或尤文肉瘤的患者，并在初始治疗前在我们的机构进行了分期扫描。我们使用Wilcoxon符号秩来评估PET/CT指标与不同患者亚组的生存率相关。使用受试者工作特征曲线分析来计算截止值。结果：我们共发现88例软组织肉瘤（51例）、骨肉瘤（26例）或尤文肉瘤（11例）。就诊时的中位年龄为40岁（范围：9-86岁）。高SUVmax与软组织肉瘤的短生存期（定义为<24个月）相关性最显著（短生存期（n = 18）的SUVmax中位数和范围为12.5（8.8-16.0），长生存期（≥24个月）（n = 31）为5.5（3.3-7.2），p = 0.001）。在尤文肉瘤中观察到类似的结果（短生存期（n = 6）的SUVmax中位数和范围为12.1（7.6-14.7），长生存期（n = 5）为3.7（3.5-5.5），p = 0.017）。然而，没有PET特异性指标，但肿瘤体积与原发性骨肉瘤的生存率显著相关（p = 0.035）（短期生存（n = 4）的中位数和范围为217 cm 3（186-349），长期生存（n = 19）的中位数和范围为60 cm 3（22-104），p = 0.035）。TLG仅在尤文肉瘤中与长生存期显著负相关（p = 0.03）。讨论：我们的分析表明，软组织、骨和尤文肉瘤的结局与不同的PET/CT指标相关。我们不能证实先前提出的基于体积的指标在软组织肉瘤中的优越性，我们发现SUVmax仍然是最好的预后因素。然而，骨肉瘤可能应该用肿瘤体积而不是FDG PET活性来评估。
Introduction: The role of positron-emission tomography/computed-tomography (PET/CT) in the management of sarcomas and as a prognostic tool has been studied. However, it remains unclear which metric is the most useful. We aimed to investigate if volume-based PET metrics (Tumor volume (TV) and total lesions glycolysis (TLG)) are superior to maximal standardized uptake value (SUVmax) and other metrics in predicting survival of patients with soft tissue and bone sarcomas. Materials and Methods: In this retrospective cohort study, we screened over 52′000 PET/CT scans to identify patients diagnosed with either soft tissue, bone or Ewing sarcoma and had a staging scan at our institution before initial therapy. We used a Wilcoxon signed-rank to assess which PET/CT metric was associated with survival in different patient subgroups. Receiver-Operating-Characteristic curve analysis was used to calculate cutoff values. Results: We identified a total of 88 patients with soft tissue (51), bone (26) or Ewing (11) sarcoma. Median age at presentation was 40 years (Range: 9–86 years). High SUVmax was most significantly associated with short survival (defined as <24 months) in soft tissue sarcoma (with a median and range of SUVmax 12.5 (8.8–16.0) in short (n = 18) and 5.5 (3.3–7.2) in long survival (≥24 months) (n = 31), with (p = 0.001). Similar results were seen in Ewing sarcoma (with a median and range of SUVmax 12.1 (7.6–14.7) in short (n = 6) and 3.7 (3.5–5.5) in long survival (n = 5), with (p = 0.017). However, no PET-specific metric but tumor-volume was significantly associated (p = 0.035) with survival in primary bone sarcomas (with a median and range of 217 cm3 (186–349) in short survival (n = 4) and 60 cm3 (22–104) in long survival (n = 19), with (p = 0.035). TLG was significantly inversely associated with long survival only in Ewing sarcoma (p = 0.03). Discussion: Our analysis shows that the outcome of soft tissue, bone and Ewing sarcomas is associated with different PET/CT metrics. We could not confirm the previously suggested superiority of volume-based metrics in soft tissue sarcomas, for which we found SUVmax to remain the best prognostic factor. However, bone sarcomas should probably be evaluated with tumor volume rather than FDG PET activity.
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影响因子：
1.6
作者：
Andersen KF;Fuglo HM;Rasmussen SH;Petersen MM;Loft A
通讯作者：
Loft A
DOI：
10.1158/1078-0432.ccr-11-2139
发表时间：
2012-04-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Herrmann K;Benz MR;Czernin J;Allen-Auerbach MS;Tap WD;Dry SM;Schuster T;Eckardt JJ;Phelps ME;Weber WA;Eilber FC
通讯作者：
Eilber FC
影响因子：
45.3
作者：
Frustaci, S;Gherlinzoni, F;Picci, P
通讯作者：
Picci, P
影响因子：
9
作者：
Eilber, Fritz C.;Brennan, Murray F.;Singer, Samuel
通讯作者：
Singer, Samuel
影响因子：
3.9
作者：
Salem, Usama;Amini, Behrang;Costelloe, Colleen M.
通讯作者：
Costelloe, Colleen M.