High prevalence and clinical impact of dynapenia and sarcopenia in Japanese patients with type 1 and type 2 diabetes: Findings from the Impact of Diabetes Mellitus on Dynapenia study.
High prevalence and clinical impact of dynapenia and sarcopenia in Japanese patients with type 1 and type 2 diabetes: Findings from the Impact of Diabetes Mellitus on Dynapenia study.
复制标题
DOI：
10.1111/jdi.13436
复制
发表时间：
2021-06
影响因子：
3.2
通讯作者：
Matsuhisa M
中科院分区：
文献类型：
--
作者：
Mori H;Kuroda A;Yoshida S;Yasuda T;Umayahara Y;Shimizu S;Ryomoto K;Yoshiuchi K;Yamamoto T;Matsuoka TA;Shimomura I;Matsuhisa M
本研究旨在阐明日本1型糖尿病和2型糖尿病患者中肌肉减少症和肌无力（分别为伴和不伴低肌肉质量的肌无力）的患病率和临床特征。这项横断面研究招募了1，328名1型糖尿病患者（n = 177），2型糖尿病患者（n = 645）和非糖尿病患者（n = 506）。肌肉减少症定义为低握力和低步态速度，骨骼肌质量指数低，而肌肉无力症定义为握力和膝关节伸展强度低，骨骼肌质量指数正常。没有肌肉减少症和运动障碍的参与者被定义为健壮的。在年龄≥65岁的受试者中，在12.2%和0.5%的非糖尿病患者、42.9%和11.4%的1型糖尿病患者以及20.9%和13.9%的2型糖尿病患者中观察到肌肉减少症和肌肉无力症。在1型糖尿病和2型糖尿病患者中，肌肉减少症患者明显更老，更瘦，并且显示出比健壮患者更高的糖尿病神经病变率。在1型糖尿病和2型糖尿病患者中，动力型患者年龄较大，并且显示出比健壮患者更高的糖尿病神经病变率和更低的估计肾小球滤过率。合并肌肉减少症和乏力症的患者表现出明显较低的身体生活质量和较高的偶然性福尔斯比健全的患者。1型糖尿病和2型糖尿病患者的肌肉减少症和肌肉无力症比非糖尿病患者更常见，这可能导致他们的生活质量受损和偶然性福尔斯。与非糖尿病和2型糖尿病患者相比，在1型糖尿病患者中高度观察到肌肉减少症。相比之下，1型和2型糖尿病患者的运动失调患病率明显高于非糖尿病患者。
The present study aimed to clarify the prevalence and clinical characteristics of sarcopenia and dynapenia, which are muscle weakness with and without low muscle mass, respectively, in Japanese patients with type 1 diabetes mellitus and type 2 diabetes mellitus. This cross‐sectional study enrolled 1,328 participants with type 1 diabetes (n = 177), type 2 diabetes (n = 645) and without diabetes (n = 506). Sarcopenia was defined as a low grip strength and slow gait speed with low skeletal muscle mass index, whereas dynapenia was defined as low strengths of grip and knee extension with a normal skeletal muscle mass index. Participants without sarcopenia and dynapenia were defined as robust. Among participants aged ≥65 years, sarcopenia and dynapenia were observed in 12.2% and 0.5% of individuals without diabetes, 42.9% and 11.4% of type 1 diabetes patients, and 20.9% and 13.9% of type 2 diabetes patients. In both type 1 diabetes and type 2 diabetes patients, sarcopenic patients were significantly older and thinner, and showed a significantly higher rate of diabetic neuropathy than robust patients. In patients with type 1 diabetes and type 2 diabetes, dynapenic patients were older, and showed a higher rate of diabetic neuropathy and lower estimated glomerular filtration rate than robust patients. Patients complicated with sarcopenia and dynapenia showed a significantly lower physical quality of life and higher rate of incidental falls than robust patients. Sarcopenia and dynapenia were more frequent in patients with type 1 diabetes and type 2 diabetes than in individuals without diabetes, which might contribute to their impaired quality of life and incidental falls. Sarcopenia was highly observed in type 1 diabetes patients compared with non‐diabetes and type 2 diabetes patients. In contrast, the prevalence of dynapenia was markedly higher in type 1 and type 2 diabetes patients compared with individuals without diabetes.
登录
查看更多内容
影响因子：
7.7
作者：
Park, Seok Won;Goodpaster, Bret H.;Newman, Anne B.
通讯作者：
Newman, Anne B.
影响因子：
5.8
作者：
Syddall, H. E.;Martin, H. J.;Harwood, R. H.;Cooper, C.;Sayer, A. Aihie
通讯作者：
Sayer, A. Aihie
影响因子：
13.2
作者：
Matsuo, Seiichi;Imai, Enyu;Hishida, Akira
通讯作者：
Hishida, Akira
影响因子：
7.7
作者：
O'Neill, Brian T.;Bhardwaj, Gourav;Kahn, C. Ronald
通讯作者：
Kahn, C. Ronald
DOI：
10.1093/gerona/glr010
发表时间：
2012-01-01
影响因子：
5.1
作者：
Manini, Todd M.;Clark, Brian C.
通讯作者：
Clark, Brian C.