Origin of the Autophagosomal Membrane in Plants.

Origin of the Autophagosomal Membrane in Plants.
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植物自噬体膜的起源

DOI:
10.3389/fpls.2016.01655
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发表时间:
2016
影响因子:
5.6
通讯作者:
Jiang L
Jiang L
中科院分区:
生物学2区
文献类型:
--
作者:
Zhuang X;Chung KP;Jiang L

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在自噬过程中,注定要降解的货物分子被隔离到称为自噬体的双膜结构中,随后与液泡融合。一个隔离膜结构(也称为吞噬细胞)从称为PAS(吞噬细胞组装位点或前自噬体结构)的平台开始,然后延伸并扩展成为完整的自噬体。自噬体形成膜的起源已被广泛研究,但在自噬领域仍然是一个谜。在酵母和哺乳动物细胞中,多种膜来源已被认为有助于自噬体在不同步骤的形成,从起始到扩增和成熟。最近在植物中的研究为我们理解自噬的保守作用和自噬体形成的潜在机制提供了重要的进展。在这里,我们将讨论和评估这些新的发现在植物中的自噬体的形成,特别关注植物自噬体膜的起源。
During autophagy, cargo molecules destined for degradation are sequestrated into a double-membrane structure called autophagosome, which subsequently fuses with the vacuole. An isolation membrane structure (also called the phagophore) initiates from the platform termed PAS (phagophore assembly site or preautophagosomal structure), which then elongates and expands to become the completed autophagosome. The origin of the membrane for autophagosome formation has been extensively investigated but remains an enigma in the field of autophagy. In yeast and mammalian cells multiple membrane sources have been suggested to contribute to autophagosome formation at different steps, from initiation through expansion and maturation. Recent studies in plants have provided a significant advance in our understanding of the conserved role of autophagy and the underlying mechanism for autophagosome formation. Here, we will discuss and evaluate these new findings on autophagosome formation in plants, with a particular focus on the origin of plant autophagosomal membranes.
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