Hemozoin as a novel adjuvant for inactivated whole virion influenza vaccine.
Hemozoin as a novel adjuvant for inactivated whole virion influenza vaccine.
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DOI：
10.1016/j.vaccine.2014.07.079
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发表时间：
2014-09-15
期刊：
影响因子：
5.5
通讯作者：
Kawaoka Y
中科院分区：
文献类型：
--
作者：
Uraki R;Das SC;Hatta M;Kiso M;Iwatsuki-Horimoto K;Ozawa M;Coban C;Ishii KJ;Kawaoka Y
由于疫苗接种是保护人类免受流感病毒感染的有效手段，因此人们不仅在开发新疫苗方面，而且在开发新佐剂以增强现有灭活疫苗的效力方面都做出了广泛的努力。在这里，我们研究了合成疟原虫色素（疟疾副产物疟原虫色素的合成版本）对小鼠模型中灭活全流感病毒疫苗效力的佐剂性。我们发现，用含疟原虫色素佐剂的灭活A/加州/04/2009（H1N1 pdm 09）或A/越南/1203/2004（H5 N1）病毒免疫两次的小鼠比用无佐剂的对应物免疫的小鼠引起更高的病毒特异性抗体应答。此外，用含疟原虫色素佐剂的灭活病毒免疫的小鼠比用无佐剂灭活疫苗免疫的小鼠更好地保护免于流感病毒的致死性攻击。我们的研究结果表明，疟原虫色素提高灭活流感病毒的免疫原性，因此是一个有前途的佐剂灭活全病毒流感疫苗。
Because vaccination is an effective means to protect humans from influenza viruses, extensive efforts have been made to develop not only new vaccines, but also for new adjuvants to enhance the efficacy of existing inactivated vaccines. Here, we examined the adjuvanticity of synthetic hemozoin, a synthetic version of the malarial by-product hemozoin, on the vaccine efficacy of inactivated whole influenza viruses in a mouse model. We found that mice immunized twice with hemozoin-adjuvanted inactivated A/California/04/2009 (H1N1pdm09) or A/Vietnam/1203/2004 (H5N1) virus elicited higher virus-specific antibody responses than did mice immunized with non-adjuvanted counterparts. Furthermore, mice immunized with hemozoin-adjuvanted inactivated viruses were better protected from lethal challenge with influenza viruses than were mice immunized with non-adjuvanted inactivated vaccines. Our results show that hemozoin improves the immunogenicity of inactivated influenza viruses, and is thus a promising adjuvant for inactivated whole virion influenza vaccines.
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DOI：
10.1084/jem.20041836
发表时间：
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期刊：
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