Multifaceted Clinical Effects of Echinochrome.

Multifaceted Clinical Effects of Echinochrome.
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DOI:
10.3390/md19080412
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发表时间:
2021-07-26
期刊:
影响因子:
5.4
通讯作者:
Han J
Han J
中科院分区:
医学2区
文献类型:
--
作者:
Kim HK;Vasileva EA;Mishchenko NP;Fedoreyev SA;Han J

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海洋药物组织色素是一种特殊的天然抗氧化剂。该药物的活性物质是棘色素A(EchA,7-乙基-2,3,5,6,8-五羟基-1,4-萘醌),海胆中最丰富的醌色素。该药物基于EchA的独特性质,同时阻断自由基反应的各个环节,在临床上用于心脏病学和眼科学。在过去的十年中,许多研究已经证明了组织色素在各种疾病模型中的有效性,而没有副作用。在这里,我们审查的各种临床效果和Ech A在眼科,心血管,脑血管,炎症,代谢和恶性疾病的作用模式的数据。
The marine drug histochrome is a special natural antioxidant. The active substance of the drug is echinochrome A (Ech A, 7-ethyl-2,3,5,6,8-pentahydroxy-1,4-naphthoquinone), the most abundant quinonoid pigment in sea urchins. The medicine is clinically used in cardiology and ophthalmology based on the unique properties of Ech A, which simultaneously block various links of free radical reactions. In the last decade, numerous studies have demonstrated the effectiveness of histochrome in various disease models without adverse effects. Here, we review the data on the various clinical effects and modes of action of Ech A in ophthalmic, cardiovascular, cerebrovascular, inflammatory, metabolic, and malignant diseases.
DOI: 10.1007/bf00950127
发表时间: 1985-07-01
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