Antimicrobial effect and membrane-active mechanism of tea polyphenols against Serratia marcescens
Antimicrobial effect and membrane-active mechanism of tea polyphenols against Serratia marcescens
复制标题
茶多酚对粘质沙雷氏菌的抗菌作用及膜活性机制
DOI：
10.1007/s11274-013-1464-4
复制
发表时间：
2014-02
影响因子：
4.1
通讯作者：
He, Yutang
中科院分区：
文献类型：
--
作者：
Li, Xuepeng;Xu, Yongxia;Sun, Tong;He, Yutang
In this study, we investigated the antimicrobial effect of tea polyphenols (TP) against Serratia marcescens and examined the related mechanism. Morphology changes of S. marcescens were first observed by transmission electron microscopy after treatment with TP, which indicated that the primary inhibition action of TP was to damage the bacterial cell membranes. The permeability of the outer and inner membrane of S. marcescens dramatically increased after TP treatment, which caused severe disruption of cell membrane, followed by the release of small cellular molecules. Furthermore, a proteomics approach based on two-dimensional gel electrophoresis and MALDI-TOF/TOF MS analysis was used to study the difference of membrane protein expression in the control and TP treatment S. marcescens. Taken together, our results first demonstrated that TP had a significant growth inhibition effect on S. marcescens through cell membrane damage.
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DOI：
--
发表时间：
1992
期刊：
Basic life sciences
影响因子：
--
作者：
R. Hemingway;P. Laks;S. Branham
通讯作者：
R. Hemingway;P. Laks;S. Branham
影响因子：
2.9
作者：
W. Reik;W. Dean
通讯作者：
W. Reik;W. Dean
影响因子：
2
作者：
Taguri, T;Tanaka, T;Kouno, I
通讯作者：
Kouno, I
影响因子：
4.4
作者：
Christine D. Wu;G. Wei
通讯作者：
Christine D. Wu;G. Wei
DOI：
10.1016/s1570-9639(02)00460-0
发表时间：
2002-12
期刊：
Biochimica et biophysica acta
影响因子：
--
作者：
H. Karring;G. Andersen;S. Thirup;J. Nyborg;L. Spremulli;B. Clark
通讯作者：
H. Karring;G. Andersen;S. Thirup;J. Nyborg;L. Spremulli;B. Clark