Glucosyl-hesperidin enhances the cyclic guanosine monophosphate-inducing effect of a green tea polyphenol EGCG

Glucosyl-hesperidin enhances the cyclic guanosine monophosphate-inducing effect of a green tea polyphenol EGCG
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葡萄糖基橙皮苷增强绿茶多酚 EGCG 的环磷酸鸟苷诱导作用

DOI:
10.1007/s11418-021-01538-6
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发表时间:
2021
期刊:
J. Nat. Med.
影响因子:
--
通讯作者:
Tachibana H.
Tachibana H.
中科院分区:
--
文献类型:
--
作者:
Kumazoe M;Tanaka Y;Yoshitomi R;Marugame Y;Lee KW;Onda H;Fujimura Y;Yonekura M;Shimamoto Y;Tachibana H.

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动物和临床研究表明,(–)-表没食子儿茶素-3-O-没食子酸酯(EGCG)是绿茶中主要生物活性多酚之一,具有多种药理作用,包括抗肥胖作用和抗炎作用。我们之前报道过第二信使环磷酸鸟苷 (cGMP) 介导其抗炎和抗癌特性。在这里,我们证明了葡萄糖基橙皮苷可增强绿茶提取物在体内的 cGMP 诱导作用。此外,葡萄糖橙皮苷的摄入增强了绿茶引起的抗炎因子、Toll 相互作用蛋白的上调。
Animal and clinical studies have revealed that (–)-epigallocatechin-3-O-gallate (EGCG), one of the major bioactive polyphenols in green tea, showed several pharmacological effects including anti-obesity effect and anti-inflammatory effect. We previously reported that the second messenger cyclic guanosine monophosphate (cGMP) mediates its anti-inflammatory and anti-cancer properties. Here we demonstrated that glucosyl-hesperidin, enhances the cGMP-inducing effects of green tea extract in vivo. Moreover, glucosyl-hesperidin intake potentiated the green tea-elicited upregulation of the anti-inflammatory factor, toll-interacting protein.
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