IL-10 promotes neuronal survival following spinal cord injury.
IL-10 promotes neuronal survival following spinal cord injury.
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DOI：
10.1016/j.expneurol.2009.08.018
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发表时间：
2009-11
影响因子：
5.3
通讯作者：
Mata, Marina
中科院分区：
文献类型：
--
作者：
Zhou, Zhigang;Peng, Xiangmin;Insolera, Ryan;Fink, David J.;Mata, Marina
We have previously reported that the anti-inflammatory cytokine IL-10 induces a number of signaling cascades through the IL-10 receptor in spinal cord neurons in vitro to activate NF-κB transcription Bcl-2 and Bcl-xL and that after exposure to glutamate IL-10 blocks cytochrome c release and caspase cleavage. In the current study we used a herpes simplex virus (HSV)-based vector to express IL-10 in spinal cord in vivo. Injection of the vector 30 minutes after lateral hemisection injury resulted in increased neuronal survival in the anterior quadrant of the spinal cord and improved motor function up to 6 weeks after injury, that correlated with translocation of p50 and p65 NF-κB to the nucleus and increased expression of Bcl-2 and Bcl-xL in anterior quadrant neurons. Inhibition of cytochrome c release and caspase 3 cleavage was seen in homogenates of injured spinal cord treated by the IL-10 vector. Taken together with in vitro studies that demonstrate direct neuroprotective effects of IL-10 acting through the neuronal IL-10 receptor, these results suggest that IL-10 may provides direct neuroprotective effects in spinal cord injury separate from and in addition to the known anti-inflammatory effects, and point to the possibility that IL-10 delivery by gene transfer may be a useful adjunctive therapy for spinal cord injury.
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影响因子：
15.1
作者：
Sloane, Evan;Ledeboer, A.;Seibert, W.;Coats, B.;van Strien, M.;Maier, S. F.;Johnson, K. W.;Chavez, R.;Watkins, L. R.;Leinwand, L.;Milligan, E. D.;Van Dam, A. M.
通讯作者：
Van Dam, A. M.
影响因子：
5.3
作者：
Plunkett, JA;Yu, CG;Yezierski, RP
通讯作者：
Yezierski, RP
影响因子：
5.1
作者：
Zhou, Z.;Peng, X.;Mata, M.
通讯作者：
Mata, M.
白介素10为神经元提供直接的营养支持。
影响因子：
4.7
作者：
Zhou Z;Peng X;Insolera R;Fink DJ;Mata M
通讯作者：
Mata M
影响因子：
5.3
作者：
Dietrich, WD;Busto, R;Bethea, JR
通讯作者：
Bethea, JR