Cell-adhesion molecule uvomorulin is localized in the intermediate junctions of adult intestinal epithelial cells.

Cell-adhesion molecule uvomorulin is localized in the intermediate junctions of adult intestinal epithelial cells.
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DOI:
10.1083/jcb.100.1.327
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发表时间:
1985-01
期刊:
The Journal of cell biology
影响因子:
--
通讯作者:
Kemler R
Kemler R
中科院分区:
其他
文献类型:
--
作者:
Boller K;Vestweber D;Kemler R

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Uvomorulin是一种细胞粘附分子,与小鼠着床前胚胎的压实过程和胚胎癌细胞的聚集有关。兔抗血清对纯化uvomorulin也反应与各种成人组织上皮细胞。在这项研究中,我们利用电镜分析研究了乌莫霉素在成人肠上皮细胞上的定位。Uvomorulin在这些细胞的中间连接处表现出高度受限的定位。讨论了乌莫霉素对肠上皮细胞可能的粘附作用。
Uvomorulin is a cell-adhesion molecule implicated in the compaction process of mouse preimplantation embryos and the aggregation of embryonal carcinoma cells. A rabbit antiserum against purified uvomorulin also reacts with epithelial cells of various adult tissues. In this study, we investigated the localization of uvomorulin on adult intestinal epithelial cells using electron microscopic analyses. Uvomorulin was shown to exhibit a highly restricted localization in the intermediate junctions of these cells. The results are discussed with respect to a possible adhesive function of uvomorulin on intestinal epithelial cells.
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