Vasculitis changes in COVID-19 survivors with persistent symptoms: an [(18)F]FDG-PET/CT study.
Vasculitis changes in COVID-19 survivors with persistent symptoms: an [(18)F]FDG-PET/CT study.
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DOI：
10.1007/s00259-020-05084-3
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发表时间：
2021-05
影响因子：
9.1
通讯作者：
Chiti A
中科院分区：
文献类型：
--
作者：
Sollini M;Ciccarelli M;Cecconi M;Aghemo A;Morelli P;Gelardi F;Chiti A
一些患者在 SARS-CoV-2 康复后出现无法解释的持续症状。我们的目的是评估 2-脱氧-2-[18F]氟-D-葡萄糖 ([18F]FDG) 是否能够表现出持续的炎症过程。在随访期间抱怨不明原因的持续症状超过 30 天的已康复的成年 COVID-19 患者被邀请参加该研究。符合纳入标准的患者通过[18F]FDG正电子发射断层扫描/计算机断层扫描（[18F]FDG-PET/CT）进行成像。根据良好的临床实践进行全身[18F]FDG-PET/CT，进行定性（与背景/肝脏比较）和半定量（目标与血池比计算为平均 SUVmax 动脉/平均 SUVmean 下腔静脉）分析。与年龄/性别相匹配的肿瘤患者的阴性随访 [18F]FDG-PET/CT 图像作为对照。曼-惠特尼检验用于检验组间差异。使用 SPSS 26 版进行分析。 10 名症状持续的康复 SARS-CoV-2 患者（七名男性和三名女性，中位年龄 52 岁，范围 46-80 岁）参与了这项研究。视觉分析的常见发现是骨髓和血管中[18F]FDG 摄取增加（分别为 8/10 和 6/10 例）。骨髓中的[18F]FDG摄取在病例和对照之间没有差异（p = 0.16）。两组的总血管评分相似（p = 0.95）。康复的 SARS-CoV-2 患者的靶标与血池比率高于对照组。尽管两组的总血管评分相似，但康复的 COVID-19 队列中三个血管区域（胸主动脉、右髂动脉和股动脉）的目标与血池比率显着高于对照组，这表明 SARS-CoV-2 会诱发血管炎症，这可能是导致症状持续存在的原因。
Several patients experience unexplained persistent symptoms after SARS-CoV-2 recovering. We aimed at evaluating if 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) was able to demonstrate a persistent inflammatory process. Recovered adult COVID-19 patients, who complained unexplained persisting symptoms for more than 30 days during the follow-up visits, were invited to participate in the study. Patients fulfilling inclusion criteria were imaged by [18F]FDG positron emission tomography/computed tomography ([18F]FDG-PET/CT). Whole-body [18F]FDG-PET/CT, performed according to good clinical practice, was qualitatively (comparison with background/liver) and semi-quantitatively (target-to-blood pool ratio calculated as average SUVmax artery/average SUVmean inferior vena cava) analyzed. Negative follow-up [18F]FDG-PET/CT images of oncologic patients matched for age/sex served as controls. Mann-Whitney test was used to test differences between groups. SPSS version 26 was used for analyses. Ten recovered SARS-CoV-2 patients (seven male and three females, median age 52 years, range 46–80) with persisting symptoms were enrolled in the study. Common findings at visual analysis were increased [18F]FDG uptake in bone marrow and blood vessels (8/10 and 6/10 cases, respectively). [18F]FDG uptake in bone marrow did not differ between cases and controls (p = 0.16). The total vascular score was similar in the two groups (p = 0.95). The target-to-blood pool ratio resulted higher in recovered SARS-CoV-2 patients than in controls. Although the total vascular score was similar in the two groups, the target-to-blood pool ratio was significantly higher in three vascular regions (thoracic aorta, right iliac artery, and femoral arteries) in the recovered COVID-19 cohort than in controls, suggesting that SARS-CoV-2 induces vascular inflammation, which may be responsible for persisting symptoms.
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DOI：
10.1007/s00259-018-3973-8
发表时间：
2018-07
影响因子：
9.1
作者：
Slart RHJA;Writing group;Reviewer group;Members of EANM Cardiovascular;Members of EANM Infection & Inflammation;Members of Committees, SNMMI Cardiovascular;Members of Council, PET Interest Group;Members of ASNC;EANM Committee Coordinator
通讯作者：
EANM Committee Coordinator
影响因子：
9.3
作者：
Jamar, Francois;Buscombe, John;Signore, Alberto
通讯作者：
Signore, Alberto
影响因子：
158.5
作者：
Feldstein, Leora R.;Rose, Erica B.;Randolph, Adrienne G.
通讯作者：
Randolph, Adrienne G.
DOI：
10.1007/s00259-014-2961-x
发表时间：
2015-02
影响因子：
9.1
作者：
Boellaard, Ronald;Delgado-Bolton, Roberto;Oyen, Wim J. G.;Giammarile, Francesco;Tatsch, Klaus;Eschner, Wolfgang;Verzijlbergen, Fred J.;Barrington, Sally F.;Pike, Lucy C.;Weber, Wolfgang A.;Stroobants, Sigrid;Delbeke, Dominique;Donohoe, Kevin J.;Holbrook, Scott;Graham, Michael M.;Testanera, Giorgio;Hoekstra, Otto S.;Zijlstra, Josee;Visser, Eric;Hoekstra, Corneline J.;Pruim, Jan;Willemsen, Antoon;Arends, Bertjan;Kotzerke, Joerg;Bockisch, Andreas;Beyer, Thomas;Chiti, Arturo;Krause, Bernd J.
通讯作者：
Krause, Bernd J.
影响因子：
4
作者：
Becker, Richard C.
通讯作者：
Becker, Richard C.