Relationship between West African ancestry with lung cancer risk and survival in African Americans.
Relationship between West African ancestry with lung cancer risk and survival in African Americans.
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DOI：
10.1007/s10552-019-01212-z
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发表时间：
2019-11
期刊：
影响因子：
--
通讯作者：
Ryan BM
中科院分区：
文献类型：
--
作者：
Mitchell KA;Shah E;Bowman ED;Zingone A;Nichols N;Pine SR;Kittles RA;Ryan BM
非裔美国人，尤其是男性，与美国所有其他种族和族裔群体相比，肺癌的发病率更高。自我报告的种族经常用于基因组研究，以获取个人的种族或民族。然而，从遗传混合物的研究中可以清楚地看到，人类的遗传变异并不像社会定义的种族类别那样分离成相同的生物学离散类别。以前的研究表明，非洲裔美国人的西非血统程度可能会导致这一人群的癌症风险，尽管很少有研究在肺癌中解决这个问题。使用100个SNP的遗传祖先面板，我们估计了1，407名自称为非洲裔美国人和2，413名欧洲裔美国人的西非，欧洲和美洲原住民血统。我们发现，增加西非血统与非洲裔美国男性肺癌风险增加相关（ORQ 5 vs Q1 = 2.55（1.45-4.48），p = 0.001），而在非洲裔美国女性中未观察到相关性（ORQ 5 vs Q1 = 0.90（0.51-1.59），p = 0.56）。在对收入和教育进行调整后，这种关系减弱了。遗传祖先不是肺癌风险或生存差异的主要贡献者。
African Americans, especially men, have a higher incidence of lung cancer compared with all other racial and ethnic groups in the US. Self-reported race is frequently used in genomic research studies to capture an individual’s race or ethnicity. However, it is clear from studies of genetic admixture that human genetic variation does not segregate into the same biologically discrete categories as socially defined categories of race. Previous studies have suggested that the degree of West African ancestry among African Americans can contribute to cancer risk in this population, though few studies have addressed this question in lung cancer. Using a genetic ancestry panel of 100 SNPs, we estimated West African, European, and Native American ancestry in 1,407 self-described African Americans and 2,413 European Americans. We found that increasing West African ancestry was associated with increased risk of lung cancer among African American men (ORQ5 vs Q1 = 2.55 (1.45–4.48), p = 0.001), while no association was observed in African American women (ORQ5 vs Q1 = 0.90 (0.51–1.59), p = 0.56). This relationship diminished following adjustment for income and education. Genetic ancestry is not a major contributor to lung cancer risk or survival disparities.
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通讯作者：
Seldin, Michael F.
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158.5
作者：
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4.5
作者：
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