Routinization of prenatal screening with the non-invasive prenatal test: pregnant women's perspectives.
Routinization of prenatal screening with the non-invasive prenatal test: pregnant women's perspectives.
复制标题
DOI：
10.1038/s41431-021-00940-8
复制
发表时间：
2022-06
影响因子：
5.2
通讯作者：
Henneman, Lidewij
中科院分区：
文献类型：
--
作者：
van der Meij, Karuna R. M.;Njio, Annabel;Martin, Linda;Gitsels-van der Wal, Janneke T.;Bekker, Mireille N.;van Vliet-Lachotzki, Elsbeth H.;van der Ven, A. Jeanine E. M.;Kater-Kuipers, Adriana;Timmermans, Danielle R. M.;Sistermans, Erik A.;Galjaard, Robert-Jan H.;Henneman, Lidewij
由于无创产前检测（NIPT）在胎儿非整倍体筛查方面的良好检测特点，其实施的需求日益强烈且不断增长。在荷兰，NIPT 在政府支持的筛查计划中提供，作为所有孕妇的一级筛查测试（TRIDENT-2 研究）。然而，有人担心该测试的有利特性可能会导致不加批判的使用，也称为常规化。本研究通过评估与常规化相关的三个方面来探讨女性对 NIPT 产前筛查的看法：知情选择、选择自由以及（个人和社会）对唐氏综合症的看法。在全国范围内，751名接受产前筛查咨询的孕妇完成了调查问卷。根据多维知情选择衡量标准 (MMIC) 的衡量，大多数受访者 (75.5%) 做出了产前筛查的知情选择。教育水平和宗教信仰是知情选择的重要预测因素。接受筛查的主要原因是“寻求安心”（25.5%），拒绝筛查的主要原因是“欢迎每个孩子”（30.6%）。大多数受访者（87.7%）没有感受到测试的社会压力。研究发现，接受测试者和拒绝测试者在个人和社会对唐氏综合症的看法上存在差异。我们的研究显示，在胎儿非整倍体筛查方面，知情决策和选择自由的比例很高，这表明从荷兰孕妇的角度来看，没有理由担心 NIPT 常规化。我们的研究结果强调了在国家筛查计划中负责任地实施 NIPT 的重要性。
Due to the favorable test characteristics of the non-invasive prenatal test (NIPT) in the screening of fetal aneuploidy, there has been a strong and growing demand for implementation. In the Netherlands, NIPT is offered within a governmentally supported screening program as a first-tier screening test for all pregnant women (TRIDENT-2 study). However, concerns have been raised that the test’s favorable characteristics might lead to uncritical use, also referred to as routinization. This study addresses women’s perspectives on prenatal screening with NIPT by evaluating three aspects related to routinization: informed choice, freedom to choose and (personal and societal) perspectives on Down syndrome. Nationwide, a questionnaire was completed by 751 pregnant women after receiving counseling for prenatal screening. Of the respondents, the majority (75.5%) made an informed choice for prenatal screening as measured by the multidimensional measure of informed choice (MMIC). Education level and religious affiliation were significant predictors of informed choice. The main reason to accept screening was “seeking reassurance” (25.5%), and the main reason to decline was “every child is welcome” (30.6%). The majority of respondents (87.7%) did not perceive societal pressure to test. Differences between test-acceptors and test-decliners in personal and societal perspectives on Down syndrome were found. Our study revealed high rates of informed decision-making and perceived freedom to choose regarding fetal aneuploidy screening, suggesting that there is little reason for concern about routinization of NIPT based on the perspectives of Dutch pregnant women. Our findings highlight the importance of responsible implementation of NIPT within a national screening program.
登录
查看更多内容
影响因子：
4.3
作者：
Gadsboll, Kasper;Petersen, Olav B.;Velissariou, Voula
通讯作者：
Velissariou, Voula
影响因子：
120.7
作者：
Kuppermann, Miriam;Pena, Sherri;Norton, Mary E.
通讯作者：
Norton, Mary E.
DOI：
10.2147/ijwh.s67124
发表时间：
2015
期刊：
International journal of women's health
影响因子：
--
作者：
Allyse M;Minear MA;Berson E;Sridhar S;Rote M;Hung A;Chandrasekharan S
通讯作者：
Chandrasekharan S
DOI：
10.1038/ejhg.2015.207
发表时间：
2016-06
期刊：
European journal of human genetics : EJHG
影响因子：
--
作者：
Lewis C;Hill M;Skirton H;Chitty LS
通讯作者：
Chitty LS
影响因子：
3.5
作者：
Collins, D
通讯作者：
Collins, D