Ankyrin domain encoding genes from an ancient horizontal transfer are functionally integrated into Nasonia developmental gene regulatory networks.
Ankyrin domain encoding genes from an ancient horizontal transfer are functionally integrated into Nasonia developmental gene regulatory networks.
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DOI：
10.1186/s13059-018-1526-x
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发表时间：
2018-09-28
期刊：
影响因子：
12.3
通讯作者：
Lynch JA
中科院分区：
文献类型：
--
作者：
Pers D;Lynch JA
调控网络如何整合更多的成分，以及新基因如何在功能上整合到成熟的发育过程中，这是两个重要而相互交织的问题，它们的答案对理解发育的进化具有重大意义。我们最近发现了一组沿黄蜂胚胎背腹(DV)轴具有强烈和特定表达模式的谱系限制基因，这可能是解决这些问题的一个强大的系统。我们试图了解这些基因的进化史，并确定它们在Nasonia DV模式系统中的功能。我们发现，新的DV基因是一个快速复制和分化的Anyrin结构域编码基因大家族的一部分，这些基因最有可能是从黄蜂超家族的共同祖先中的原核生物水平转移而来的。我们测试了这些沿着DV轴表达的Ankyrin编码基因的功能，发现它们参与了早期胚胎DV的形成。我们还开发了一个新的黄蜂模型系统(Melittobia)，发现Anyrin基因的一些功能整合已经保存了9000多万年。我们的结果表明，调控网络可以整合新的基因，这些基因随后成为稳定和可重复输出所必需的。即使在发育网络中扮演一个适度的角色，也可能足以使新的或重复的基因保持在基因组中，并成为完全整合的网络组件。本文的在线版本(10.1186/s13059-0181526-x)包含向授权用户提供的补充材料。
How regulatory networks incorporate additional components and how novel genes are functionally integrated into well-established developmental processes are two important and intertwined questions whose answers have major implications for understanding the evolution of development. We recently discovered a set of lineage-restricted genes with strong and specific expression patterns along the dorsal-ventral (DV) axis of the embryo of the wasp Nasonia that may serve as a powerful system for addressing these questions. We sought to both understand the evolutionary history of these genes and to determine their functions in the Nasonia DV patterning system. We have found that the novel DV genes are part of a large family of rapidly duplicating and diverging ankyrin domain-encoding genes that originated most likely by horizontal transfer from a prokaryote in a common ancestor of the wasp superfamily Chalcidoidea. We tested the function of those ankyrin-encoding genes expressed along the DV axis and found that they participate in early embryonic DV patterning. We also developed a new wasp model system (Melittobia) and found that some functional integration of ankyrin genes have been preserved for over 90 million years. Our results indicate that regulatory networks can incorporate novel genes that then become necessary for stable and repeatable outputs. Even a modest role in developmental networks may be enough to allow novel or duplicate genes to be maintained in the genome and become fully integrated network components. The online version of this article (10.1186/s13059-018-1526-x) contains supplementary material, which is available to authorized users.
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影响因子：
1.6
作者：
Mercer, AA;Fleming, SB;Ueda, N
通讯作者：
Ueda, N
影响因子：
12.3
作者：
Capra JA;Pollard KS;Singh M
通讯作者：
Singh M
DOI：
10.1002/prot.340170405
发表时间：
1993-12-01
期刊：
PROTEINS-STRUCTURE FUNCTION AND GENETICS
影响因子：
--
作者：
BORK, P
通讯作者：
BORK, P
影响因子：
9.2
作者：
Gavin-Smyth, Jackie;Wang, Yu-Chiun;Ferguson, Edwin L.
通讯作者：
Ferguson, Edwin L.
DOI：
10.1098/rspb.2000.1418
发表时间：
2001-04-07
影响因子：
4.7
作者：
Machado, CA;Jousselin, E;Herre, EA
通讯作者：
Herre, EA