The effects of aging and sex on detection of ultrasonic vocalizations by adult CBA/CaJ mice (Mus musculus).
The effects of aging and sex on detection of ultrasonic vocalizations by adult CBA/CaJ mice (Mus musculus).
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DOI：
10.1016/j.heares.2016.08.014
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发表时间：
2016-11
期刊：
影响因子：
2.8
通讯作者：
Dent, Micheal L.
中科院分区：
文献类型：
--
作者：
Kobrina, Anastasiya;Dent, Micheal L.
小鼠经常被用作人类听力研究的动物模型，但它们的听觉能力尚未得到充分的探索。先前的研究已经利用ABR和行为学方法建立了CBA/CaJ小鼠对纯音刺激的听阈敏感性。人们对它们如何感知自己的超声波发声（usv）知之甚少，对衰老如何影响这种感知也一无所知。本研究的目的是建立几种USV类型的听觉阈值敏感性，并在小鼠的整个生命周期中跟踪这些阈值。为了确定小鼠对这些复杂的通信刺激的检测能力，我们使用操作性条件反射程序对不同年龄的几只CBA/CaJ小鼠进行了检测任务的训练和测试。结果表明，小鼠在老年时仍能检测到usv。毫不奇怪，不同USV类型的阈值不同。在所有的呼叫中，雄性老鼠的听力损失都比雌性大，但在42千赫的音调中没有。总之，研究结果强调了研究生命周期中复杂信号的重要性。
Mice are frequently used as animal models for human hearing research, yet their auditory capabilities have not been fully explored. Previous studies have established auditory threshold sensitivities for pure tone stimuli in CBA/CaJ mice using ABR and behavioral methodologies. Little is known about how they perceive their own ultrasonic vocalizations (USVs), and nothing is known about how aging influences this perception. The aim of the present study is to establish auditory threshold sensitivity for several USV types, as well as to track these thresholds across the mouse’s lifespan. In order to determine how well mice detect these complex communication stimuli, several CBA/CaJ mice were trained and tested at various ages on a detection task using operant conditioning procedures. Results showed that mice were able to detect USVs into old age. Not surprisingly, thresholds differed for the different USV types. Male mice suffered greater hearing loss than females for all calls but not for 42 kHz tones. In conclusion, the results highlight the importance of studying complex signals across the lifespan.
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DOI：
10.1007/bf00610446
发表时间：
1989-01-01
影响因子：
2.1
作者：
KLUMP, GM;MAIER, EH
通讯作者：
MAIER, EH
影响因子：
3
作者：
Chabout, Jonathan;Sarkar, Abhra;Jarvis, Erich D.
通讯作者：
Jarvis, Erich D.
DOI：
10.1007/s10162-010-0228-1
发表时间：
2010-12-01
影响因子：
2.4
作者：
Ohlemiller, Kevin K.;Dahl, Ashley R.;Gagnon, Patricia M.
通讯作者：
Gagnon, Patricia M.
影响因子：
5.4
作者：
Klink, Karin B.;Bendig, Garnet;Klump, Georg M.
通讯作者：
Klump, Georg M.
影响因子：
2.8
作者：
Henry, KR
通讯作者：
Henry, KR