miR-320a is an independent prognostic biomarker for invasive breast cancer.
miR-320a is an independent prognostic biomarker for invasive breast cancer.
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DOI：
10.3892/ol.2014.2298
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发表时间：
2014-09
期刊：
影响因子：
2.9
通讯作者：
Liu X
中科院分区：
文献类型：
--
作者：
Yang H;Yu J;Wang L;Ding D;Zhang L;Chu C;Chen Q;Xu Z;Zou Q;Liu X
乳腺癌是全球最常见的恶性肿瘤之一，也是女性癌症相关死亡的第二大原因。miRNA是一类在人类癌症中异常表达的小的非编码RNA。由于它们的小尺寸和稳定性，miRNA具有成为有效临床靶标的潜力。microRNA-320 a（miR-320 a）在多种恶性肿瘤中表达异常。本研究检测了15例原位乳腺癌和130例浸润性乳腺癌组织中miR-320 a的表达水平，并评估其对乳腺癌患者预后的价值。显色原位杂交显示60/130（46%）浸润性乳腺癌组织显示miR-320 a高表达水平（染色指数评分≥4）。miR-320 a表达与肿瘤大小（P=0.046）、临床分期（P<0.001）、淋巴结转移（P<0.001）和远处转移（P=0.006）相关。此外，表现出低miR-320 a表达水平的患者具有较短的总生存时间（P<0.001）。单变量和多变量分析显示，miR-320 a是浸润性乳腺癌的独立预后生物标志物（风险比，0.221; 95%置信区间，0.050-0.979; P=0.047）。受试者操作特征曲线显示，与广泛使用的浸润性乳腺癌预后生物标志物（雌激素受体、孕激素受体和人表皮生长因子-2）相比，miR-320 a的预后价值增强。本研究的结果表明，miR-320 a是浸润性乳腺癌预后的潜在生物标志物，miR-320 a的失调可能参与浸润性乳腺癌的进展。
Breast cancer is one of the most common malignancies worldwide and is the second leading cause of cancer-related mortality among females. miRNAs are a class of small noncoding RNAs that are aberrantly expressed in human cancers. Due to their small size and stability, miRNAs have the potential to be efficacious clinical targets. MicroRNA-320a (miR-320a) has been shown to be dysregulated in multiple malignancies. In the present study, the expression levels of miR-320a were investigated in 15 paraffin-embedded in situ breast carcinoma and 130 invasive breast cancer tissues, and the prognostic value for breast cancer patients was assessed. Chromogenic in situ hybridization revealed that 60/130 (46%) invasive breast cancer tissues exhibited high expression levels of miR-320a (staining index score of ≥4). Furthermore, miR-320a staining was found to significantly correlate with tumor size (P=0.046), clinical stage (P<0.001), lymph node metastasis (P<0.001) and distant metastasis (P=0.006). In addition, patients exhibiting low miR-320a expression levels had shorter overall survival times (P<0.001). Univariate and multivariate analyses revealed that miR-320a was an independent prognostic biomarker for invasive breast cancer (hazard ratio, 0.221; 95% confidence interval, 0.050–0.979; P=0.047). Receiver operator characteristic curves revealed that the prognostic value of miR-320a was enhanced when compared with the widely used prognostic biomarkers (estrogen receptor, progesterone receptor and human epidermal growth factor-2) in invasive breast cancer. The results of the present study suggest that miR-320a presents a potential biomarker for the prognosis of invasive breast cancer, and dysregulation of miR-320a may be involved in invasive breast cancer progression.
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影响因子：
20.3
作者：
Diakos, Christofer;Zhong, Sheng;Wiemels, Joseph L.
通讯作者：
Wiemels, Joseph L.
影响因子：
8.8
作者：
Wu, W.;Takanashi, M.;Bodigin, N.;Ohno, S-i;Fujita, K.;Hoshino, S.;Osaka, Y.;Tsuchida, A.;Kurode, M.
通讯作者：
Kurode, M.
影响因子：
5.7
作者：
Salendo, Junius;Spitzner, Melanie;Gaedcke, Jochen
通讯作者：
Gaedcke, Jochen
DOI：
10.1038/labinvest.2012.119
发表时间：
2012-10
期刊：
Laboratory investigation; a journal of technical methods and pathology
影响因子：
--
作者：
通讯作者：
--
影响因子：
6.2
作者：
Wu, Zheng-sheng;Wu, Qiang;Zhang, Nong
通讯作者：
Zhang, Nong