Neurophysiological evidence for remediation of reward processing deficits in chronic pain and opioid misuse following treatment with Mindfulness-Oriented Recovery Enhancement: exploratory ERP findings from a pilot RCT.
Neurophysiological evidence for remediation of reward processing deficits in chronic pain and opioid misuse following treatment with Mindfulness-Oriented Recovery Enhancement: exploratory ERP findings from a pilot RCT.
复制标题
神经生理学证据，用于修复慢性疼痛和阿片类药物滥用中奖励处理缺陷的缺陷，并以正念为导向的恢复增强：探索性ERP的发现。
DOI：
10.1007/s10865-014-9607-0
复制
发表时间：
2015-04
影响因子：
3.1
通讯作者：
Howard, Matthew O.
中科院分区：
文献类型：
--
作者：
Garland, Eric L.;Froeliger, Brett;Howard, Matthew O.
自然奖励加工失调可能是慢性疼痛患者处方阿片类药物滥用和成瘾的病因和维持的中心致病过程。本研究考察了正念导向的恢复增强（MORE）干预是否可以通过事件相关脑电位（ERPs）显示的味觉训练来增强自然奖励加工。参与者是有阿片类药物滥用风险的慢性疼痛患者，他们被随机分为8周MORE组（n=11）或支持组对照组（n=18）。在8周的治疗前后分别测量代表自然奖励刺激的图像（例如，美丽的风景，亲密的夫妇）和中性图像的erp。分析的重点是后期正电位(LPP) -一种在400 - 1000 ms时间窗内的ERP反应，被认为是对情绪信息的注意分配的指标。与中性刺激相比，使用MORE治疗与LPP对自然奖励刺激的反应显著增加有关，这与治疗前到治疗后增强的积极情感线索反应和阿片类药物渴望的减少有关。研究结果表明，以加强对自然奖励的关注为中心的认知训练方案可能会弥补导致成瘾行为的奖励处理缺陷。
Dysregulated processing of natural rewards may be a central pathogenic process in the etiology and maintenance of prescription opioid misuse and addiction among chronic pain patients. This study examined whether a Mindfulness-Oriented Recovery Enhancement (MORE) intervention could enhance natural reward processing through training in savoring as indicated by event-related brain potentials (ERPs). Participants were chronic pain patients at risk for opioid misuse who were randomized to eight weeks of MORE (n=11) or a support group control condition (n=18). ERPs to images representing naturally rewarding stimuli (e.g., beautiful landscapes, intimate couples) and neutral images were measured before and after 8 weeks of treatment. Analyses focused on the late positive potential (LPP) - an ERP response in the 400 – 1000 ms time window thought to index allocation of attention to emotional information. Treatment with MORE was associated with significant increases in LPP response to natural reward stimuli relative to neutral stimuli which were correlated with enhanced positive affective cue-responses and reductions in opioid craving from pre- to post-treatment. Findings suggest that cognitive training regimens centered on strengthening attention to natural rewards may remediate reward processing deficits underpinning addictive behavior.
登录
查看更多内容
DOI：
10.1016/j.jpain.2008.10.008
发表时间：
2009-02
期刊：
The journal of pain
影响因子：
--
作者：
Chou R;Fanciullo GJ;Fine PG;Adler JA;Ballantyne JC;Davies P;Donovan MI;Fishbain DA;Foley KM;Fudin J;Gilson AM;Kelter A;Mauskop A;O'Connor PG;Passik SD;Pasternak GW;Portenoy RK;Rich BA;Roberts RG;Todd KH;Miaskowski C;American Pain Society-American Academy of Pain Medicine Opioids Guidelines Panel
通讯作者：
American Pain Society-American Academy of Pain Medicine Opioids Guidelines Panel
影响因子：
7.4
作者：
Butler, Stephen F.;Budman, Simon H.;Jamison, Robert N.
通讯作者：
Jamison, Robert N.
影响因子：
17.7
作者：
Kalivas, PW;Volkow, ND
通讯作者：
Volkow, ND
影响因子：
3.1
作者：
Hagerty MR;Isaacs J;Brasington L;Shupe L;Fetz EE;Cramer SC
通讯作者：
Cramer SC
影响因子：
4.7
作者：
Garland EL;Froeliger B;Howard MO
通讯作者：
Howard MO