Diminished Auditory Cortex Dynamic Range and its Clinical Correlates in First Episode Psychosis.
Diminished Auditory Cortex Dynamic Range and its Clinical Correlates in First Episode Psychosis.
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首发精神病中听觉皮层动态范围的减少及其临床相关性。
DOI：
10.1093/schbul/sbac208
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发表时间：
2023
影响因子：
6.6
通讯作者：
Salisbury,DeanF
中科院分区：
文献类型：
--
作者：
Sklar,AlfredoL;Ren,Xi;Chlpka,Lydia;Curtis,Mark;Coffman,BrianA;Salisbury,DeanF
背景和假设越来越多的人认识到感觉障碍对精神病发病率的影响。本研究检查了听觉皮层（AC）的动态范围：研究目的：探讨精神分裂症谱系疾病（FESz）患者对刺激强度的神经生理反应及其与发病时临床结局的关系。研究设计：对35名FESz患者和40名健康对照者（HC）进行了脑磁图（MEG）记录（75 dB、80 dB和85 dB）。磁共振成像，以提高皮层定位的MEG传感器水平的活动。所有参与者完成了MATRICS认知成套测验（MCCB）和全球功能：角色和社会量表（GFR/GFS）。患者被管理的阳性和阴性症状量表（PANSS）。研究结果FESz表现出减少AC反应相对于HC。AC活动的增强，以增加强度的音调在FESz相对于HC钝化。减小的动态范围（85-75 dB AC响应）与较低的GFS相关（r= .58）和GFR（r= .45）评分，MCCB性能较差（r= .45），PANSS阴性症状子量表评分增加（r=-0.55）在FESz中，未观察到与对单个音调的AC反应的关系。FESz表现出相对于HC减小的动态范围。这种损害与疾病发病率的标志物相关，包括较差的社区功能以及认知和阴性症状。与受损的社会功能的关系可能反映了AC动态范围在解码语言的情感内容中的作用，并强调了其对未来治疗感觉补救方案的重要性。
Background and HypothesisThere is growing appreciation for the contribution of sensory disruptions to disease morbidity in psychosis. The present study examined auditory cortex (AC) dynamic range: the scaling of neurophysiological responses to stimulus intensity, among individuals with a schizophrenia spectrum illness (FESz) and its relationship to clinical outcomes at disease onset.Study DesignMagnetoencephalography (MEG) was recorded from 35 FESz and 40 healthy controls (HC) during binaural presentation of tones at three intensities (75 dB, 80 dB, and 85 dB). MRIs were obtained to enhance cortical localization of MEG sensor-level activity. All participants completed the MATRICS cognitive battery (MCCB) and Global Functioning: Role and Social scales (GFR/GFS). Patients were administered the Positive and Negative Syndrome Scale (PANSS).Study ResultsFESz exhibited reduced AC response relative to HC. Enhancement of AC activity to tones of increasing intensity was blunted in FESz relative to HC. Reduced dynamic range (85–75 dB AC response) was associated with lower GFS (r= .58) and GFR (r= .45) scores, worse MCCB performance (r= .45), and increased PANSS Negative symptom subscale scores (r= −.55) among FESz, relationships not observed with AC responses to individual tones.ConclusionBeyond an impaired AC response to pure tones, FESz exhibit reduced dynamic range relative to HC. This impairment was correlated with markers of disease morbidity including poorer community functioning as well as cognitive and negative symptoms. The relationship with impaired social functioning may reflect the role of AC dynamic range in decoding the emotional content of language and highlights its importance to future therapeutic sensory remediation protocols.
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影响因子：
4.5
作者：
Young;Eun;Hyang;S. Hahn;Seung
通讯作者：
Seung
影响因子：
6.6
作者：
Charlson, Fiona J.;Ferrari, Alize J.;Whiteford, Harvey A.
通讯作者：
Whiteford, Harvey A.
使用脑磁图定位精神分裂症谱系疾病发作的早期视觉处理缺陷。
影响因子：
6.6
作者：
Sklar,AlfredoL;Coffman,BrianA;Salisbury,DeanF
通讯作者：
Salisbury,DeanF
DOI：
10.1176/ajp.2007.164.3.474
发表时间：
2007-03
期刊：
The American journal of psychiatry
影响因子：
--
作者：
D. Leitman;M. Hoptman;John J. Foxe;Erica Saccente;G. Wylie;J. Nierenberg;M. Jalbrzikowski;K. Lim;D. Javitt
通讯作者：
D. Leitman;M. Hoptman;John J. Foxe;Erica Saccente;G. Wylie;J. Nierenberg;M. Jalbrzikowski;K. Lim;D. Javitt
影响因子：
5.3
作者：
Cloutier, Martin;Aigbogun, Myrlene Sanon;Wu, Eric
通讯作者：
Wu, Eric