Spirochaetes in oral infections.

Spirochaetes in oral infections.
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口腔感染中的螺旋体。

DOI:
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发表时间:
1993
期刊:
Endodontics & dental traumatology
影响因子:
--
通讯作者:
Ingar Olsen
Ingar Olsen
中科院分区:
--
文献类型:
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作者:
Ulf R Dahle;Leif Tronstad;Ingar Olsen

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口腔螺旋体是小型、中型或大型的,包括密螺旋体属的物种,其中许多尚未被培养。它们在根管感染、冠周炎、牙龈炎和牙周炎中被发现,在牙髓脓肿中占植物群的10%,在急性坏死性溃疡性牙龈炎中占30%,在晚期边缘牙周炎中占56%。这些微生物的强蛋白水解活性可能使它们成为感染的原因而不是后果。由于能够穿透组织,它们将其酶,代谢产物和内毒素与靶细胞直接接触。这可能干扰宿主细胞和免疫球蛋白的基本功能。酶活性也可能有助于满足螺旋体在体内复杂的生长要求。感染的牙周组织和梅毒螺旋体的单克隆抗体之间的反应表明,不明病原体相关的口腔螺旋体的表面结构和功能类似于这种公认的病原体。这就需要更深入地研究螺旋体在口腔感染中的作用。
Oral spirochaetes, which are small-, medium- or large-sized, include species of the genus Treponema, many of which have not yet been cultured. They are found in root canal infections, pericoronitis, gingivitis and periodontitis, constituting up to 10% of the flora in endodontic abscesses, 30% in acute necrotizing ulcerative gingivitis, and 56% in advanced marginal periodontitis. The strong proteolytic activity of these organisms probably make them causes of infection rather than consequences. Being able to penetrate tissue, they bring their enzymes, metabolic products, and endotoxins, in direct contact with target cells. This may perturb essential functions of host cells and immunoglobulins. Enzyme activities may also help fulfil the complex growth requirements of spirochaetes in vivo. Reaction between infected periodontal tissue and monoclonal antibodies to Treponema pallidum has suggested that uncharacterized pathogen-related oral spirochaetes have surface structures and functions analogue to this well recognized pathogen. This warrants a more intensified search for the role of spirochaetes in oral infections.
DOI: 10.1128/jcm.30.2.418-426.1992
发表时间: 1992-02
影响因子: 9.4
作者:
W. J. Loesche;D. Lopatin;'. J. Stoll;'. Neal;Van;Poperin;P. Hujoel
通讯作者: W. J. Loesche;D. Lopatin;'. J. Stoll;'. Neal;Van;Poperin;P. Hujoel
某些龈下微生物物种在选定牙周条件下的分布。
DOI: 10.1111/j.1600-0765.1984.tb00800.x
发表时间: 1984
影响因子: 3.5
作者:
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DOI: 10.1111/j.1600-051x.1986.tb00878.x
发表时间: 1986
影响因子: 6.7
作者:
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通讯作者: Dougherty,P
使用随机克隆的 DNA 片段来鉴定口腔螺旋体。
DOI: 10.1111/j.1399-302x.1991.tb00457.x
发表时间: 1991
影响因子: --
作者:
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通讯作者: Boehringer,H
口腔螺旋体抑制人类淋巴细胞反应:单核细胞依赖性现象。
DOI: --
发表时间: 1984
期刊: Journal of immunology (Baltimore, Md. : 1950)
影响因子: --
作者:
Shenker,BJ;Listgarten,MA;Taichman,NS
通讯作者: Taichman,NS