Adolescents with Classical Polycystic Ovary Syndrome Have Alterations in the Surrogate Markers of Cardiovascular Disease but Not in the Endothelial Function. The Possible Benefits of Metformin.
Adolescents with Classical Polycystic Ovary Syndrome Have Alterations in the Surrogate Markers of Cardiovascular Disease but Not in the Endothelial Function. The Possible Benefits of Metformin.
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DOI：
10.1016/j.jpag.2016.03.004
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发表时间：
2016-10
影响因子：
1.8
通讯作者：
Taddei S
中科院分区：
文献类型：
--
作者：
Fruzzetti F;Ghiadoni L;Virdis A;De Negri F;Perini D;Bucci F;Giannarelli C;Gadducci A;Taddei S
探讨青少年多囊卵巢综合征经典型是否存在代谢和血管结构功能的改变。评价二甲双胍的疗效。对照研究大学门诊纳入18名多囊卵巢综合征非肥胖青少年。17名年龄匹配的健康青少年被招募作为对照。评估代谢谱和内皮结构和功能。测量激素和血脂、血压（BP）、空腹血糖和胰岛素水平、c反应蛋白（CRP）、同型半胱氨酸、组织型纤溶酶原激活剂（t-PA）、纤溶酶原激活剂抑制剂-1 （PAI-1）和纤溶酶抗纤溶酶复合物（PAP）。血流介导扩张（FMD）、中央脉波速度（PWV）、桡动脉脉波（AIx）和颈总动脉内膜-中膜厚度（IMT）也进行了评估。多囊卵巢综合征（PCOS）女孩也接受二甲双胍（850毫克/次）治疗6个月后的研究。多囊卵巢综合征青少年胰岛素抵抗和/或高胰岛素血症，他们的血压值和CRP和PAI-1水平高于对照组。两组患者t-PA和PAP水平相似。口蹄疫、PWV和IMT也相似。二甲双胍显著降低胰岛素、血压、CRP和PAI-1水平（p<0.05）。PAP水平显著升高（p<0.05）。二甲双胍后桡骨AIx明显降低。FMD、PWV和IMT均无变化。患有经典多囊卵巢综合征的青少年有一些心血管危险的替代标志物的改变，二甲双胍可以改善这些标志物。没有发现血管结构和功能的恶化，可能是由于暴露于疾病的时间短。
To study whether adolescents with the classical form of polycystic ovary syndrome have alterations in metabolic and vascular structure and function. The effect of metformin was evaluated. Controlled study University outpatient clinic Eighteen PCOS non obese adolescents were enrolled. Seventeen healthy age-matched adolescents were recruited as controls. The metabolic profile and the endothelial structure and function were evaluated. Hormonal and lipid profile, blood pressure (BP) measurement, fasting glucose and insulin levels, C-reactive protein (CRP), homocysteine, tissue-type plasminogen activator (t-PA), plasminogen activator inhibitor-1 (PAI-1) and plasmin-antiplasmin complexes (PAP) were measured. Flow mediated dilation (FMD), central pulse wave velocity (PWV), radial artery pulse wave (AIx) and common carotid intima-media thickness (IMT) were also assessed. PCOS girls were also studied 6 months after treatment with metformin (850 mg bid). PCOS adolescents were insulin resistant and/or hyperinsulinemic and they had higher BP values and levels of CRP and PAI-1 than the controls. The levels of t-PA and PAP were similar in both groups. FMD, PWV and IMT were also similar. Metformin significantly (p<0.05) reduced insulin, BP, CRP and PAI-1 levels. The PAP levels significantly (p<0.05) increased. Radial AIx was significantly reduced after metformin. No modifications in FMD, PWV and IMT were observed. Adolescents with classical PCOS have alterations in some surrogate markers of cardiovascular risk and they are ameliorated by metformin. No deterioration of vascular structure and function has been detected, probably due to the short duration of exposure to the disease.
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影响因子：
13.3
作者：
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通讯作者：
Balen, A
影响因子：
6.7
作者：
Fruzzetti, Franca;Perini, Daria;Genazzani, Andandrea R.
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作者：
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通讯作者：
Dabadghao, P.
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作者：
Carmina, E.
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