The chernobyl tissue bank - a repository for biomaterial and data used in integrative and systems biology modeling the human response to radiation.
The chernobyl tissue bank - a repository for biomaterial and data used in integrative and systems biology modeling the human response to radiation.
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DOI：
10.3390/genes3020278
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发表时间：
2012-05-09
期刊：
影响因子：
3.5
通讯作者：
Butcher S
中科院分区：
文献类型：
--
作者：
Thomas G;Unger K;Krznaric M;Galpine A;Bethel J;Tomlinson C;Woodbridge M;Butcher S
切尔诺贝利事故对人类健康的唯一明确的辐射影响是儿童或青春期早期受辐射者甲状腺癌的增加。为了响应研究切尔诺贝利后甲状腺癌分子生物学的科学兴趣，切尔诺贝利组织库（CTB：）于1998年成立。到目前为止，它已收集了3 861人的生物样本，并提供了27个研究项目的11 254个样本。CTB从一开始就被设计为一种资源，以促进研究和临床数据的整合，促进对辐射相关甲状腺癌采取系统生物学方法。因此，该项目已发展成为临床医生，剂量学家，分子生物学家和生物信息学家之间的多学科合作，并作为组学时代组织库的典范。
The only unequivocal radiological effect of the Chernobyl accident on human health is the increase in thyroid cancer in those exposed in childhood or early adolescence. In response to the scientific interest in studying the molecular biology of thyroid cancer post Chernobyl, the Chernobyl Tissue Bank (CTB: ) was established in 1998. Thus far it is has collected biological samples from 3,861 individuals, and provided 27 research projects with 11,254 samples. The CTB was designed from its outset as a resource to promote the integration of research and clinical data to facilitate a systems biology approach to radiation related thyroid cancer. The project has therefore developed as a multidisciplinary collaboration between clinicians, dosimetrists, molecular biologists and bioinformaticians and serves as a paradigm for tissue banking in the omics era.
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