Cerebral lactate dynamics across sleep/wake cycles.
Cerebral lactate dynamics across sleep/wake cycles.
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DOI：
10.3389/fncom.2014.00174
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发表时间：
2014
影响因子：
3.2
通讯作者：
Wisor JP
中科院分区：
文献类型：
--
作者：
Rempe MJ;Wisor JP
大脑的新陈代谢随着睡眠状态的变化而变化。乳酸盐的脑浓度（通过糖酵解利用葡萄糖的最终产物）作为睡眠状态的函数而变化，并且像脑电图（EEG）中的慢波活动（SWA）一样，作为清醒或快速眼动睡眠中花费的时间的函数而增加，并且作为慢波睡眠（SWS）中花费的时间的函数而下降。我们试图确定乳酸浓度是否表现出类似于SWS中SWA的稳态动力学。通过留置酶生物传感器测量大脑皮层中的乳酸浓度。一组方程概念上的基础上的过程S（以前用于量化的稳态动态SWA）被用来预测的睡眠/觉醒状态依赖的动态乳酸浓度在大脑皮层。此外，我们采用了迭代参数空间限制算法（Nelder-Mead方法），以减少计算时间，找到最佳值的自由参数。与穷举搜索相比，该算法所需的计算时间减少了几个数量级。我们发现，状态依赖的乳酸浓度动态可以描述的稳态模型，但用于描述乳酸动力学的最佳时间常数比SWA小得多。乳酸动力学和SWA动力学之间的这种脱节不支持乳酸浓度是睡眠稳态的生化介质的概念。然而，大脑皮层中的乳酸合成可能仍然是关于睡眠功能的信息，因为糖酵解对睡眠慢波调节的影响只是现在才被研究。
Cerebral metabolism varies dramatically as a function of sleep state. Brain concentration of lactate, the end product of glucose utilization via glycolysis, varies as a function of sleep state, and like slow wave activity (SWA) in the electroencephalogram (EEG), increases as a function of time spent awake or in rapid eye movement sleep and declines as a function of time spent in slow wave sleep (SWS). We sought to determine whether lactate concentration exhibits homeostatic dynamics akin to those of SWA in SWS. Lactate concentration in the cerebral cortex was measured by indwelling enzymatic biosensors. A set of equations based conceptually on Process S (previously used to quantify the homeostatic dynamics of SWA) was used to predict the sleep/wake state-dependent dynamics of lactate concentration in the cerebral cortex. Additionally, we applied an iterative parameter space-restricting algorithm (the Nelder-Mead method) to reduce computational time to find the optimal values of the free parameters. Compared to an exhaustive search, this algorithm reduced the computation time required by orders of magnitude. We show that state-dependent lactate concentration dynamics can be described by a homeostatic model, but that the optimal time constants for describing lactate dynamics are much smaller than those of SWA. This disconnect between lactate dynamics and SWA dynamics does not support the concept that lactate concentration is a biochemical mediator of sleep homeostasis. However, lactate synthesis in the cerebral cortex may nonetheless be informative with regard to sleep function, since the impact of glycolysis on sleep slow wave regulation is only just now being investigated.
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