In Silico Quantification of Intersubject Variability on Aerosol Deposition in the Oral Airway.
In Silico Quantification of Intersubject Variability on Aerosol Deposition in the Oral Airway.
复制标题
口腔气道中气溶胶沉积的受试者间变异性的计算机量化。
DOI：
10.3390/pharmaceutics15010160
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发表时间：
2023-01-03
期刊：
影响因子：
5.4
通讯作者：
Darquenne C
中科院分区：
文献类型：
--
作者：
Borojeni AAT;Gu W;Asgharian B;Price O;Kuprat AP;Singh RK;Colby S;Corley RA;Darquenne C
胸外口腔气道不仅是药物气雾剂到达肺部的主要机械屏障，也是肺部沉积变异性的主要来源。使用计算流体动力学，在11个基于CT的成人口腔气道模型中预测了1-30 µm颗粒的沉积。在代表静息/雾化器使用（18 L/min）和干粉吸入器（DPI）使用（45 L/min）的两种稳态流速下，对吸气和呼气期间的口呼吸进行模拟。与先前的体外研究一致，口腔沉积存在较大的受试者间变异性。对于1-5 µm的药物气雾剂的最佳粒径分布，我们的数据表明，当使用雾化器时，大多数受试者中>75%的吸入气雾剂被递送到胸内肺，但当使用DPI时，仅约一半的受试者被递送到胸内肺。吸气和呼气之间的口腔沉积效率没有显著差异，不像次区域沉积，其在两个呼吸阶段之间显示出显著不同的模式。这些结果突出了需要将上气道的形态变化的气溶胶沉积的预测模型中的肺的胸内区域的粒子剂量的准确预测。
The extrathoracic oral airway is not only a major mechanical barrier for pharmaceutical aerosols to reach the lung but also a major source of variability in lung deposition. Using computational fluid dynamics, deposition of 1–30 µm particles was predicted in 11 CT-based models of the oral airways of adults. Simulations were performed for mouth breathing during both inspiration and expiration at two steady-state flow rates representative of resting/nebulizer use (18 L/min) and of dry powder inhaler (DPI) use (45 L/min). Consistent with previous in vitro studies, there was a large intersubject variability in oral deposition. For an optimal size distribution of 1–5 µm for pharmaceutical aerosols, our data suggest that >75% of the inhaled aerosol is delivered to the intrathoracic lungs in most subjects when using a nebulizer but only in about half the subjects when using a DPI. There was no significant difference in oral deposition efficiency between inspiration and expiration, unlike subregional deposition, which shows significantly different patterns between the two breathing phases. These results highlight the need for incorporating a morphological variation of the upper airway in predictive models of aerosol deposition for accurate predictions of particle dosimetry in the intrathoracic region of the lung.
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DOI：
10.1177/0194599820959674
发表时间：
2021-04
期刊：
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
影响因子：
--
作者：
Frank-Ito DO;Cohen SM
通讯作者：
Cohen SM
影响因子：
4.5
作者：
Feng, Yu;Zhao, Jianan;Yi, Hang
通讯作者：
Yi, Hang
影响因子：
3.3
作者：
Kelly, JT;Prasad, AK;Wexler, AS
通讯作者：
Wexler, AS
影响因子：
--
作者：
DelGaudio, JM
通讯作者：
DelGaudio, JM
DOI：
10.1007/s11548-019-02023-y
发表时间：
2020-01-01
影响因子：
3
作者：
Borojeni, Azadeh A. T.;Garcia, Guilherme J. M.;Rhee, John S.
通讯作者：
Rhee, John S.