Orally Inhaled Drug Particle Transport in Computerized Models of Laryngotracheal Stenosis.
Orally Inhaled Drug Particle Transport in Computerized Models of Laryngotracheal Stenosis.
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DOI：
10.1177/0194599820959674
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发表时间：
2021-04
期刊：
影响因子：
--
通讯作者：
Cohen SM
中科院分区：
文献类型：
--
作者：
Frank-Ito DO;Cohen SM
喉气管狭窄（LTS）的辅助治疗可能涉及吸入皮质类固醇，但定量吸入器设计用于肺部给药。目前缺乏对LTS狭窄患者口服吸入皮质类固醇药物颗粒沉积效率的综合分析。描述性研究学术医学中心上气道的解剖学上逼真的三维重建是从四个LTS受试者的计算机断层扫描图像创建的-两个声门下狭窄和两个气管狭窄受试者。计算流体动力学模型用于模拟每个气道中的气流和药物颗粒运输。模拟三种吸入压力，10 Pa、25 Pa和40 Pa。模拟100-950纳米颗粒和1-50微米颗粒的药物颗粒转运。将颗粒释放到气道中以模拟具有和不具有间隔室的不同吸入器条件。基于最小与最大横截面积比，声门下狭窄模型的喉气管狭窄段分别缩小了57%和47%，两种气管狭窄模型均缩小了53%。声门下狭窄模型的狭窄段气流阻力低于气管狭窄模型：0.001-0.011Pa.s/ml比0.024-0.082Pa.s/ml。对于声门下狭窄和气管狭窄模型，狭窄处微米颗粒和纳米颗粒的药物沉积分别为0.06%-2.48%和0.10%-2.60%。声门下狭窄模型中狭窄沉积最高的颗粒尺寸为6μm-20μm，气管狭窄模型中为1μm-10μm。该研究表明，最多2.60%的吸入药物颗粒存款在狭窄处。具有最高狭窄沉积的颗粒尺寸范围可能并不代表吸入器排放的典型尺寸。
Adjuvant management for laryngotracheal stenosis (LTS) may involve inhaled corticosteroids, but metered dose inhalers are designed for pulmonary drug delivery. Comprehensive analyses of drug particle deposition efficiency for orally inhaled corticosteroids in the stenosis of LTS subjects are lacking. Descriptive Research Academic medical center Anatomically realistic three-dimensional reconstructions of the upper airway were created from computed tomography images of four LTS subjects – two subglottic stenosis and two tracheal stenosis subjects. Computational fluid dynamics modeling was used to simulate airflow and drug particle transport in each airway. Three inhalation pressures were simulated, 10Pa, 25Pa, and 40Pa. Drug particle transport was simulated for 100–950 nanoparticles and 1–50 micron-particles. Particles were released into the airway to mimic varying inhaler conditions with and without a spacer chamber. Based on smallest to largest cross-sectional area ratio, the laryngotracheal stenotic segment shrunk by 57% and 47%, respectively, for subglottic stenosis models and by 53% for both tracheal stenosis models. Airflow resistance at stenotic segment was lower in subglottic stenosis models than in tracheal stenosis models: 0.001–0.011Pa.s/ml versus 0.024–0.082Pa.s/ml. Drug depositions for micron-particles and nanoparticles at stenosis were 0.06%−2.48% and 0.10%−2.60% for subglottic stenosis and tracheal stenosis models, respectively. Particle sizes with highest stenotic deposition were 6μm-20μm for subglottic stenosis models and 1μm-10μm for tracheal stenosis models. This study suggests that at most 2.60% of inhaled drug particles deposit at the stenosis. Particle size ranges with highest stenotic deposition may not represent typical sizes emitted by inhalers.
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影响因子：
7.8
作者：
Gelbard, Alexander;Anderson, Catherine;Francis, David O.
通讯作者：
Francis, David O.
影响因子：
5.9
作者：
Crim, C;Holmes, M;Lincourt, W
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5.2
作者：
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DOI：
10.1016/0731-7085(96)01730-x
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1996-05-01
影响因子：
3.4
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影响因子：
2.6
作者：
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