Astrocyte Diversity: Current Insights and Future Directions.
Astrocyte Diversity: Current Insights and Future Directions.
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星形胶质细胞多样性：当前的见解和未来的方向。
DOI：
10.1007/s11064-020-02959-7
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发表时间：
2020-06
影响因子：
4.4
通讯作者：
Rothstein JD
中科院分区：
文献类型：
--
作者：
Westergard T;Rothstein JD
星形胶质细胞占中枢神经系统（CNS）内神经胶质细胞的20-40%，并提供多种重要功能，从代谢和结构支持到突触发生和突触传递的调节。虽然这些细胞在形态和功能上都很复杂，但星形胶质细胞在历史上一直被认为是同质的细胞群，并作为一个细胞群进行研究。幸运的是，最近RNA分析和成像数据的证据已经开始反驳这一观点。这些研究表明，整个大脑区域的星形胶质细胞具有异质性，在形态、功能、生理特性、发育起源和对疾病的反应等许多方面存在差异。增加对星形胶质细胞异质性的理解对于研究星形胶质细胞在脑中的功能和神经胶质细胞相互作用至关重要。此外，对星形胶质细胞异质性的深入了解可以帮助更好地了解它们在神经系统疾病中的作用，并可能产生治疗这些疾病的新方法。
Astrocytes make up 20–40% of glial cells within the central nervous system (CNS) and provide several crucial functions, ranging from metabolic and structural support to regulation of synaptogenesis and synaptic transmission. Although these cells are morphologically and functionally complex, astrocytes have been historically regarded as homogenous cell populations and studied as one population of cells. Fortunately, recent evidence in RNA profiling and imaging data has begun to refute this view. These studies suggest heterogeneity of astrocytes across brain regions, differing in many aspects such as morphology, function, physiological properties, developmental origins, and response to disease. Increased understanding of astrocyte heterogeneity is critical for investigations into the function of astrocytes in the brain and neuro-glia interactions. Furthermore, insights into astrocyte heterogeneity can help better understand their role in neurological disorders and potentially produce novel approaches to treating these diseases.
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影响因子：
34.7
作者：
Clarke, Laura E.;Barres, Ben A.
通讯作者：
Barres, Ben A.
影响因子：
15.3
作者：
Brambilla, R;Bracchi-Ricard, V;Hu, WH;Frydel, B;Bramwell, A;Karmally, S;Green, EJ;Bethea, JR
通讯作者：
Bethea, JR
影响因子：
16.2
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通讯作者：
Deneen B
影响因子：
2.1
作者：
Ferrari R;Kapogiannis D;Huey ED;Momeni P
通讯作者：
Momeni P
影响因子：
--
作者：
Emsley, Jason G.;Macklis, Jeffrey D.
通讯作者：
Macklis, Jeffrey D.