Glial development: the crossroads of regeneration and repair in the CNS.
Glial development: the crossroads of regeneration and repair in the CNS.
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DOI：
10.1016/j.neuron.2014.06.010
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发表时间：
2014-07-16
期刊：
影响因子：
16.2
通讯作者：
Deneen B
中科院分区：
文献类型：
--
作者：
Gallo V;Deneen B
鉴于哺乳动物中枢神经系统的复杂性，其再生被视为再生医学的圣杯。为了理解发育神经发生，人们做出了非凡的努力，希望将这些知识应用于临床。CNS再生还涉及神经胶质，其构成脑的细胞组成的至少50%，并且涉及所有形式的损伤和疾病反应、恢复和再生。最近的发展研究给了我们前所未有的洞察过程中，调节中枢神经系统胶质细胞的产生。由于恢复过程往往平行于那些发现在发展中，我们将通过透镜的发育胶质细胞再生，以获得一个更清楚的了解病理条件下的神经胶质细胞再生的过程。具体而言，本次审查将集中在关键的信号通路，调节星形胶质细胞和少突胶质细胞的发展，并描述这些机制是如何在这些人群中重新利用在CNS损伤后的再生和修复。
Given the complexities of the mammalian CNS, its regeneration is viewed as the holy grail of regenerative medicine. Extraordinary efforts have been made to understand developmental neurogenesis, with the hopes of clinically applying this knowledge. CNS regeneration also involves glia, which comprises at least 50% of the cellular constituency of the brain, and is involved in all forms of injury and disease response, recovery and regeneration. Recent developmental studies have given us unprecedented insight into the processes that regulate the generation of CNS glia. Because restorative processes often parallel those found in development, we will peer through the lens of developmental gliogenesis to gain a clearer understanding of the processes that underlie glial regeneration under pathological conditions. Specifically, this review will focus on key signaling pathways that regulate astrocyte and oligodendrocyte development, and describe how these mechanisms are reutilized in these populations during regeneration and repair after CNS injury.
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影响因子：
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作者：
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