Role of microbiota on lung homeostasis and diseases.
Role of microbiota on lung homeostasis and diseases.
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微生物群对肺稳态和疾病的作用
DOI：
10.1007/s11427-017-9151-1
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发表时间：
2017-12
期刊：
影响因子：
--
通讯作者：
Tian Z
中科院分区：
文献类型：
--
作者：
Wang J;Li F;Tian Z
肺部作为气体交换的场所，持续暴露于环境刺激，例如过敏原、微生物和污染物。用于微生物分析的非培养技术（如16 S rRNA测序）的发展揭示了肺不是无菌的，事实上，肺中存在不同的微生物群。肠道微生物群在调节粘膜稳态和防御中的功能已被广泛研究;然而，肺微生物群在调节免疫和稳态中的潜在功能才刚刚开始。越来越多的证据表明微生物群与肺内稳态和疾病相关。在这篇综述中，我们描述了呼吸系统中微生物群的分布和组成，并讨论了肺部微生物群在健康和急性/慢性肺部疾病中的潜在功能。此外，我们还讨论了最近对肠-肺轴的理解，因为一些研究表明肠道、肺和微生物群之间的免疫相互作用参与了这个问题。
The lungs, as a place of gas exchange, are continuously exposed to environmental stimuli, such as allergens, microbes, and pollutants. The development of the culture-independent technique for microbiological analysis, such as 16S rRNA sequencing, has uncovered that the lungs are not sterile and, in fact, colonized by diverse communities of microbiota. The function of intestinal microbiota in modulating mucosal homeostasis and defense has been widely studied; however, the potential function of lung microbiota in regulating immunity and homeostasis has just begun. Increasing evidence indicates the relevance of microbiota to lung homeostasis and disease. In this review, we describe the distribution and composition of microbiota in the respiratory system and discuss the potential function of lung microbiota in both health and acute/chronic lung disease. In addition, we also discuss the recent understanding of the gut-lung axis, because several studies have revealed that the immunological interaction among the gut, the lung, and the microbiota was involved in this issue.
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影响因子：
64.8
作者：
Glenwright AJ;Pothula KR;Bhamidimarri SP;Chorev DS;Baslé A;Firbank SJ;Zheng H;Robinson CV;Winterhalter M;Kleinekathöfer U;Bolam DN;van den Berg B
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