Interpreting global trends in type 2 diabetes complications and mortality.

Interpreting global trends in type 2 diabetes complications and mortality.
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DOI:
10.1007/s00125-021-05585-2
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发表时间:
2022-01
期刊:
影响因子:
8.2
通讯作者:
Gregg EW
Gregg EW
中科院分区:
医学1区
文献类型:
--
作者:
Ali MK;Pearson-Stuttard J;Selvin E;Gregg EW

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传统糖尿病并发症(心血管、肾脏、外周血管、眼科、肝脏或神经系统疾病)和死亡率的国际趋势特征不佳。早些时候发布的对截至2015年的研究的回顾表明,大多数数据来自北美、欧洲或亚太地区的十几个高收入国家(HIC),至少在这些国家,需要就医和截肢、心肌梗死和死亡率的急性血糖波动比率在此期间都在下降。在这里,我们提供了自2015年以来关于成人2型糖尿病并发症和死亡率趋势的最新文献综述。我们还讨论了与数据收集、分析和报告相关的问题,这些问题已经影响了2型糖尿病及其并发症的全球趋势。我们发现,大多数关于2型糖尿病及其并发症和死亡率的趋势的数据来自少数拥有全面监测系统的HIC,尽管至少有一些来自非洲和拉丁美洲的低收入和中等收入国家(LMIC)参与了这项审查。公布的数据表明,糖尿病患者的心血管并发症发生率和各种原因的死亡率都有所下降。与此同时,糖尿病患者的心血管并发症和死亡率随着时间的推移而在LMICs中增加。然而,在解释LMIC的趋势时需要谨慎,因为数据极其稀少,或者数据在各国之间不具有可比性。我们注意到,病例确定的方法以及并发症和死亡率(分子)和2型糖尿病(分母)的定义差异很大,并影响对国际数据的解释。我们提出了四项关键建议,以更严格地记录随着时间的推移和全球范围内2型糖尿病并发症和死亡率的趋势:(1)增加对数据收集系统的投资;(2)标准化病例定义和确定方法;(3)加强分析能力;(4)制定和实施结构化的数据报告指南。
International trends in traditional diabetes complications (cardiovascular, renal, peripheral vascular, ophthalmic, hepatic or neurological diseases) and mortality rates are poorly characterised. An earlier review of studies published up to 2015 demonstrated that most data come from a dozen high-income countries (HICs) in North America, Europe or the Asia–Pacific region and that, in these countries at least, rates of acute glycaemic fluctuations needing medical attention and amputations, myocardial infarction and mortality were all declining over the period. Here, we provide an updated review of published literature on trends in type 2 diabetes complications and mortality in adults since 2015. We also discuss issues related to data collection, analysis and reporting that have influenced global trends in type 2 diabetes and its complications. We found that most data on trends in type 2 diabetes, its complications and mortality come from a small number of HICs with comprehensive surveillance systems, though at least some low- and middle-income countries (LMICs) from Africa and Latin America are represented in this review. The published data suggest that HICs have experienced declines in cardiovascular complication rates and all-cause mortality in people with diabetes. In parallel, cardiovascular complications and mortality rates in people with diabetes have increased over time in LMICs. However, caution is warranted in interpreting trends from LMICs due to extremely sparse data or data that are not comparable across countries. We noted that approaches to case ascertainment and definitions of complications and mortality (numerators) and type 2 diabetes (the denominator) vary widely and influence the interpretation of international data. We offer four key recommendations to more rigorously document trends in rates of type 2 diabetes complications and mortality, over time and worldwide: (1) increasing investments in data collection systems; (2) standardising case definitions and approaches to ascertainment; (3) strengthening analytical capacity; and (4) developing and implementing structured guidelines for reporting of data.
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