Gelsolin as a Potential Biomarker for Endoscopic Activity and Mucosal Healing in Ulcerative Colitis.
Gelsolin as a Potential Biomarker for Endoscopic Activity and Mucosal Healing in Ulcerative Colitis.
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凝胶胶作为溃疡性结肠炎内镜活动和粘膜愈合的潜在生物标志物。
DOI：
10.3390/biomedicines10040872
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发表时间：
2022-04-09
期刊：
影响因子：
4.7
通讯作者：
中科院分区：
文献类型：
--
作者：
溃疡性结肠炎的治疗目标是粘膜愈合，这需要改进非侵入性生物标志物来评估疾病活动。Gelsolin与几种自身免疫性疾病相关，在这里，我们的目的是分析其作为溃疡性结肠炎临床和内镜活动的血清学生物标志物的实用性。溃疡性结肠炎患者（n = 138）接受了血液检查和结肠镜检查。采用酶联免疫吸附法测定血清明胶含量，并检测明胶水平与临床和内镜活动的相关性。溃疡性结肠炎患者血清gelsolin水平明显低于健康人，且随Mayo评分和Mayo内镜亚评分的升高而成比例降低。临床和内镜下缓解与血清凝胶水平的相关性曲线下面积大于c反应蛋白。此外，在c反应蛋白阴性的患者中，活动性阶段的血清凝胶水平低于缓解期。我们的研究结果表明，血清凝胶蛋白水平与溃疡性结肠炎的临床和内镜活动相关，比c反应蛋白具有更高的敏感性和特异性，并且可以检测粘膜愈合，提示凝胶蛋白可以作为溃疡性结肠炎的生物标志物。
The therapeutic goal in ulcerative colitis is mucosal healing, which requires improved non-invasive biomarkers to evaluate disease activity. Gelsolin is associated with several autoimmune diseases, and here, we aimed to analyze its usefulness as a serological biomarker for clinical and endoscopic activities in ulcerative colitis. Patients with ulcerative colitis (n = 138) who had undergone blood tests and colonoscopy were included. Serum gelsolin was measured using enzyme-linked immunosorbent assay, and correlation between the gelsolin level and clinical and endoscopic activities was examined. The serum gelsolin level in patients with ulcerative colitis was significantly lower than that in healthy subjects, and it decreased in proportion to increasing Mayo score and Mayo endoscopic subscore. The area under the curve for correlation between clinical and endoscopic remission and serum gelsolin level was higher than that for C-reactive protein. Furthermore, in C-reactive protein-negative patients, the serum gelsolin level was lower in the active phase than in remission. Our findings indicate that the serum gelsolin level correlates with clinical and endoscopic activities in ulcerative colitis, has a higher sensitivity and specificity than C-reactive protein, and can detect mucosal healing, suggesting that gelsolin can be used as a biomarker for ulcerative colitis.
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