Epidemiological features of amyotrophic lateral sclerosis in a large clinic-based African American population.
Epidemiological features of amyotrophic lateral sclerosis in a large clinic-based African American population.
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DOI：
10.3109/21678421.2013.770030
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发表时间：
2013-09
影响因子：
2.8
通讯作者：
King PH
中科院分区：
文献类型：
--
作者：
Kazamel M;Cutter G;Claussen G;Alsharabati M;Oh SJ;Lu L;King PH
确定非裔美国人（AA）患者的主要临床和流行病学特征，并将其与临床人群中的高加索人（CA）患者进行比较。根据修订的El Escorial标准，我们回顾性地确定了207例被诊断为ALS的患者（60例AA和147例CA受试者）。患者在大学医学中心的神经肌肉科就诊。我们比较两组患者的流行病学和临床特征，重点关注发病年龄、诊断年龄、临床表现和生存率。AA患者的发病年龄明显较年轻（55岁对61岁，p=0.011），且诊断年龄较早（56岁对62岁，p=0.012）。在年龄较小（<45岁）的ALS患者中，性别频率差异有统计学意义，AA人群中以女性为主，CA人群中以男性为主（p = 0.025）。在多变量Cox比例风险模型中，两组之间的存活率没有差异。两组患者的存活率都随着年龄的增长而显著增加。AA患者出现年龄较早，但与CA患者相比，生存率无差异。性别逆转发生在年轻的ALS患者中，AA患者更可能是女性，CA患者更可能是男性。
To identify the main clinical and epidemiological features of ALS in a large cohort of African American (AA) patients and compare them to Caucasian (CA) patients in a clinic-based population. We retrospectively identified 207 patients who were diagnosed with ALS based on the revised El Escorial criteria (60 AA and 147 CA subjects). Patients were seen in the Neuromuscular Division at the University Medical Center. We compared epidemiological and clinical features of these two groups, focusing on age of onset and diagnosis, clinical presentation and survival. AA patients had a significantly younger age of disease onset (55 years v. 61 for CA, p=0.011) and were diagnosed at an earlier age (56 v. 62, p=0.012). In younger ALS patients (<45 years old), there was a significant difference in gender frequency, with females predominating in the AA population and males in the CA population (p = 0.025). In a multivariable Cox proportional hazard model, survival rates were not different between the groups. In both groups, survival significantly increased with younger age. AA patients presented at an earlier age, but there was no difference in survival compared to CA patients. A gender reversal occurred in younger ALS patients, with AA patients more likely to be female and CA patients more likely to be male.
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影响因子：
9.9
作者：
Zaldivar, T.;Gutierrez, J.;Hardiman, O.
通讯作者：
Hardiman, O.
DOI：
10.1136/jnnp.2009.183525
发表时间：
2010-04
期刊：
Journal of neurology, neurosurgery, and psychiatry
影响因子：
--
作者：
Logroscino G;Traynor BJ;Hardiman O;Chiò A;Mitchell D;Swingler RJ;Millul A;Benn E;Beghi E;EURALS
通讯作者：
EURALS
影响因子：
14.5
作者：
Turner, Martin R.;Barnwell, Jessica;Eisen, Andrew
通讯作者：
Eisen, Andrew
影响因子：
14.5
作者：
OSUNTOKUN, BO;ADEUJA, AOG;BADEMOSI, O
通讯作者：
BADEMOSI, O
影响因子：
9.9
作者：
del Aguila, MA;Longstreth, WT;van Belle, G
通讯作者：
van Belle, G