Incidence of amyotrophic lateral sclerosis in Europe.
Incidence of amyotrophic lateral sclerosis in Europe.
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DOI：
10.1136/jnnp.2009.183525
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发表时间：
2010-04
期刊：
影响因子：
--
通讯作者：
EURALS
中科院分区：
文献类型：
--
作者：
Logroscino G;Traynor BJ;Hardiman O;Chiò A;Mitchell D;Swingler RJ;Millul A;Benn E;Beghi E;EURALS
肌萎缩侧索硬化症（ALS）发病率的地理差异已在文献中报道，但由于病例确定方法不同以及研究人群规模相对较小，以往研究的比较受到限制。为了解决这些问题，作者对欧洲基于人群的ALS登记进行了汇总分析。1998-1999年两年期间，在3个欧洲国家（爱尔兰、英国、意大利）的6个基于人群的登记研究中前瞻性确定了18岁及以上受试者中所有新发ALS病例，参考人群近2400万。基于1，028例确定的事件病例，欧洲一般人群中ALS的粗年发病率为2.16/100，000人-年; 95% CI 2.0-2.3），所有登记研究的发病率相似。男性的发病率（3.0/100，000人-年; 95% CI = 2.8 - 3.3）高于女性（2.4/100，000人-年; 95% CI=2.2 - 2.6）。脊髓型ALS在男性中比女性更常见，特别是在70-80岁年龄组中。80岁以后发病率迅速下降。ALS的发病率在整个欧洲是均匀的。发病率的性别差异可以解释为男性中脊髓型ALS的发病率较高，年龄相关疾病模式表明ALS发生在人群中的易感人群中，而不是衰老疾病。
Geographical differences in amyotrophic lateral sclerosis (ALS) incidence have been reported in the literature, but comparisons across previous studies are limited by different methods in case ascertainment and by the relatively small size of the studied populations. To address these issues, the authors undertook a pooled-analysis of European population-based ALS registries. All new incident ALS cases in subjects 18 years old and older were identified prospectively in six population-based registries in three European countries (Ireland, United Kingdom, Italy) in the two year period 1998-1999 with a reference population of almost 24 million. Based on 1,028 identified incident cases, the crude annual incidence rate of ALS in the general European population was 2.16 per 100,000 person-years; 95% CI 2.0-2.3), with similar incidence rates across all registries. The incidence was higher among men (3.0 per 100,000 person-years; 95% CI = 2.8 to 3.3) than among women (2.4 per 100,000 person-years; 95% CI=2.2 to 2.6). Spinal onset ALS was more common among men compared to women, particularly in the 70-80 year age group. Disease occurrence decreases rapidly after 80 years of age. ALS incidence is homogeneous across Europe. Sex differences in incidence may be explained by the higher incidence of spinal onset ALS among males and the age-related disease pattern suggests that ALS occurs within a susceptible group within the population rather than being a disease of aging.
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影响因子：
9.9
作者：
Zaldivar, T.;Gutierrez, J.;Hardiman, O.
通讯作者：
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影响因子：
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影响因子：
9.9
作者：
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