Concise review: Leukemia stem cells in personalized medicine.
Concise review: Leukemia stem cells in personalized medicine.
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DOI：
10.1002/stem.1597
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发表时间：
2014-04
期刊：
影响因子：
5.2
通讯作者：
Allan, John N.
中科院分区：
文献类型：
--
作者：
Guzman, Monica L.;Allan, John N.
关键词：
尽管对AML发病机制的理解有所增加，但目前的治疗策略在改善标准诱导化疗以诱导长期缓解方面做得很少。自从白血病干细胞的鉴定以来，人们一直在努力鉴定区分这种日益重要的细胞区室的治疗上可行的途径。随着基因组测序工作和表型表征的增加，个性化治疗策略的机会正在迅速出现。在这篇综述中，我们强调了白血病干细胞生物学的理解及其转化为临床相关疗法的潜力的最新进展。NF-κ B活化、Bcl-2表达、氧化和代谢状态以及表观遗传修饰都具有其自身的临床意义。随着遗传学、表观遗传学和代谢谱的进步，个性化策略在不久的将来可能是可行的，以改善AML患者的预后。
Despite increased comprehension of AML pathogenesis, current treatment strategies have done little to improve upon standard induction chemotherapy to induce long-term remissions. Since the identification of the leukemic stem cell, efforts have been placed on identifying therapeutically actionable pathways that distinguish this increasingly important cellular compartment. With the advent of increased genome sequencing efforts and phenotypic characterization, opportunities for personalized treatment strategies are rapidly emerging. In this review, we highlight recent advances in the understanding of leukemic stem cell biology and their potential for translation into clinically relevant therapeutics. NF-kappa B activation, Bcl-2 expression, oxidative and metabolic state, and epigenetic modifications all bear their own clinical implications. With advancements in genetic, epigenetic, and metabolic profiling, personalized strategies may be feasible in the near future to improve outcomes for AML patients.
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影响因子：
11.2
作者：
Chakrabarty A;Bhola NE;Sutton C;Ghosh R;Kuba MG;Dave B;Chang JC;Arteaga CL
通讯作者：
Arteaga CL
DOI：
10.1084/jem.20100523
发表时间：
2010-04-12
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Abdel-Wahab O;Levine RL
通讯作者：
Levine RL
影响因子：
50.3
作者：
Figueroa ME;Abdel-Wahab O;Lu C;Ward PS;Patel J;Shih A;Li Y;Bhagwat N;Vasanthakumar A;Fernandez HF;Tallman MS;Sun Z;Wolniak K;Peeters JK;Liu W;Choe SE;Fantin VR;Paietta E;Löwenberg B;Licht JD;Godley LA;Delwel R;Valk PJ;Thompson CB;Levine RL;Melnick A
通讯作者：
Melnick A
影响因子：
20.3
作者：
Guzman, ML;Neering, SJ;Jordan, CT
通讯作者：
Jordan, CT
影响因子：
82.9
作者：
Eppert, Kolja;Takenaka, Katsuto;Dick, John E.
通讯作者：
Dick, John E.