Transmission of scotopic signals from the rod to rod-bipolar cell in the mammalian retina

Transmission of scotopic signals from the rod to rod-bipolar cell in the mammalian retina
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哺乳动物视网膜中暗视信号从视杆细胞到视杆双极细胞的传输

DOI:
10.1016/j.visres.2004.07.043
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发表时间:
2004
期刊:
影响因子:
1.8
通讯作者:
Robert G. Smith
Robert G. Smith
中科院分区:
心理学3区
文献类型:
--
作者:
W. Taylor;Robert G. Smith

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哺乳动物可以在低暗光水平下看到东西,其中数千只杆中只有一根可以转换光子。单光子信号由神经节细胞传输到大脑,神经节细胞收集来自 1000 多个杆的信号以提供足够的放大。如果系统是线性的,这种收敛会增加神经噪声,足以压倒微小的杆信号。最近的研究提供了杆对杆双极突触阈值非线性的证据,它消除了大部分背景神经噪声。我们认为阈值的高度应该是单光子信号幅度的 0.85 倍,这与观察到的单光子信号饱和度一致。在这个水平上,由于神经噪声导致的误报事件的发生率将被较高的暗热事件发生率所掩盖。所提供的证据表明,该突触经过优化,可以在低暗光水平下传输单光子信号。
Mammals can see at low scotopic light levels where only 1 rod in several thousand transduces a photon. The single photon signal is transmitted to the brain by the ganglion cell, which collects signals from more than 1000 rods to provide enough amplification. If the system were linear, such convergence would increase the neural noise enough to overwhelm the tiny rod signal. Recent studies provide evidence for a threshold nonlinearity in the rod to rod bipolar synapse, which removes much of the background neural noise. We argue that the height of the threshold should be 0.85 times the amplitude of the single photon signal, consistent with the saturation observed for the single photon signal. At this level, the rate of false positive events due to neural noise would be masked by the higher rate of dark thermal events. The evidence presented suggests that this synapse is optimized to transmit the single photon signal at low scotopic light levels.
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