White matter integrity is a stronger predictor of motor function than BOLD response in patients with stroke.
White matter integrity is a stronger predictor of motor function than BOLD response in patients with stroke.
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在中风患者中，白质完整性比 BOLD 反应更能预测运动功能。
DOI：
10.1177/1545968310389183
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发表时间：
2011-03
影响因子：
4.2
通讯作者：
Butler AJ
中科院分区：
文献类型：
--
作者：
Qiu M;Darling WG;Morecraft RJ;Ni CC;Rajendra J;Butler AJ
神经影像学技术，如扩散张量成像（DTI）和血氧水平依赖性（BOLD）功能磁共振成像（fMRI），提供了深入了解脑卒中后皮质运动系统的功能重组。本研究探讨上肢运动功能、白色质完整性与皮质运动区BOLD反应的关系。17例患者符合研究入选标准;其中12例完成了白色完整性的DTI评估，9例完成了运动相关激活的fMRI评估。主要临床结局指标为Wolf运动功能测试（WMFT）和Fugl-Meyer（FM）运动评估的上肢部分。通过检查PLIC中的各向异性分数（FA）不对称性来评估内囊后肢的结构完整性。在手指捏任务期间，测量每个患者的运动皮层区的偏侧性指数作为BOLD反应。进行线性回归分析，以确定临床结果是否与结构或功能MRI测量相关。临床结果测量与FA不对称性之间存在很强的相关性（例如，FM评分[R2 = .655，P = .001]和WMFT不对称性评分[R2 = .651，P < .002]），但与fMRI测量的相关性较弱。在卒中后3 ~ 9个月，临床运动功能与内囊白色物质完整性的关系比与运动区BOLD反应的关系更密切。因此，使用DTI来评估内囊白色物质的完整性可能比功能磁共振成像提供更有用的信息来解释幕上脑损伤后的运动障碍。
Neuroimaging techniques, such as diffusion tensor imaging (DTI) and blood oxygenation level–dependent (BOLD) functional magnetic resonance imaging (fMRI), provide insights into the functional reorganization of the cortical motor system after stroke. This study explores the relationship between upper extremity motor function, white matter integrity, and BOLD response of cortical motor areas. Seventeen patients met study inclusion criteria; of these 12 completed DTI assessment of white matter integrity and 9 completed fMRI assessment of motor-related activation. Primary clinical outcome measures were the Wolf Motor Function Test (WMFT) and the upper limb portion of the Fugl-Meyer (FM) motor assessment. Structural integrity of the posterior limb of the internal capsule was assessed by examining the fractional anisotropy (FA) asymmetry in the PLIC. Laterality index of motor cortical areas was measured as the BOLD response in each patient during a finger pinch task. Linear regression analyses were performed to determine whether clinical outcome was associated with structural or functional MRI measures. There were strong relationships between clinical outcome measures and FA asymmetry (eg, FM score [R2 = .655, P = .001] and WMFT asymmetry score [R2 = .651, P < .002]) but relationships with fMRI measures were weaker. Clinical motor function is more closely related to the white matter integrity of the internal capsule than to BOLD response of motor areas in patients 3 to 9 months after stroke. Thus, use of DTI to assess white matter integrity in the internal capsule may provide more useful information than fMRI to interpret motor deficits following supratentorial brain injury.
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影响因子：
2.1
作者：
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