Regulation of Lysophosphatidic Acid Metabolism and Signaling by Lipoproteins.
Regulation of Lysophosphatidic Acid Metabolism and Signaling by Lipoproteins.
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脂蛋白对溶血磷脂酸代谢和信号传导的调节。
DOI：
10.1161/atvbaha.116.308237
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Smyth,SusanS
中科院分区：
文献类型：
--
作者：
Morris,AndrewJ;Smyth,SusanS
2030 Arterioscler Thromb Vasc Biol 2016年10月渗透性和血管生成失调。13尽管需要更多的细胞类型的细节和其他机制是合理的，但可以推测，在动脉粥样硬化的发展过程中，血管内皮细胞中可遗传的LPP 3亚型和因此增强的LPA信号传导可能有助于增加斑块血管生成。LDL与自分泌运动因子基因表达调控的相关机制在本研究中尚未探讨，但肯定值得研究。在啮齿动物和人类中，自分泌运动因子表达加工和分泌的调节是复杂的，但由于脂肪组织似乎是自分泌运动因子表达的主要系统性位点，大多数研究报道了在肥胖相关的脂肪组织扩张期间自分泌运动因子表达增加。14然而，这可能在多大程度上导致肥胖高脂血症患者循环自分泌运动因子和LPA水平升高仍有待确定。血浆LPA与肠源性和肝源性低密度脂蛋白和血清白蛋白相关。虽然最近的研究表明，脂蛋白伴侣改变相关的生物活性脂质鞘氨醇1磷酸的信号转导特性，低密度脂蛋白相关的LPA的生物活性知之甚少。由于LPA是哺乳动物细胞和动物模型中自分泌运动因子表达的有效抑制剂，15因此，LDL相关LPA可能负责形成发育中的斑马鱼胚胎中LDL水平和自分泌运动因子表达之间相互关系的传感机制。LDL水平，autotaxin表达和LPA信号之间的关系的进一步探索无疑将揭示肥胖，高脂血症和血管病变之间的联系的新方面。
2030 Arterioscler Thromb Vasc Biol October 2016 permeability and dysregulated angiogenesis. 13 Although more details of the cell types involved are needed and other mechanisms are plausible, one could speculate that heritable LPP3 hypomorphism and consequently heightened LPA signaling in vascular endothelial cells might contribute to increased plaque angiogenesis during the development of atherosclerosis. The mechanisms linking LDL to regulation of autotaxin gene expression were not explored in the present study but would certainly be worth pursuing. Regulation of autotaxin expression processing and secretion in rodents and humans is complicated but because adipose tissue seems to be a major systemic site of autotaxin expression, most studies have reported increased autotaxin expression during obesityassociated adipose tissue expansion. 14 However, the extent to which this might contribute to elevated circulating autotaxin and LPA levels in obese hyperlipidemic humans remains to be determined. Plasma LPA is associated with both intestinal and liver-derived low-density lipoproteins and serum albumin. Although recent studies suggest that lipoprotein chaperones alter the signaling properties of the related bioactive lipid sphingosine 1 phosphate, little is known about the biological activities of low-density lipoprotein–associated LPA. Because LPA is a potent suppressor of autotaxin expression in mammalian cells and animal models, 15 it is possible that LDL-associated LPA is responsible for the sensing mechanism that underlies the reciprocal relationship between LDL levels and autotaxin expression in the developing zebrafish embryo. Further exploration of the relationships between LDL levels, autotaxin expression, and LPA signaling will undoubtedly reveal new facets of the links between obesity, hyperlipidemia, and vascular pathologies.
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影响因子：
--
作者：
GRANTHAM, JJ;BURG, MB
通讯作者：
BURG, MB
影响因子：
4.1
作者：
CHABARDES, D;MONTEGUT, M;MOREL, F
通讯作者：
MOREL, F
加压素荧光光亲和类似物的合成和生物活性。
影响因子：
4.8
作者：
Buku,A;Schwartz,IL;Gazis,D;Ma,CL;Eggena,P
通讯作者：
Eggena,P
肾集合管中加压素结合的细胞特异性：荧光激素类似物的计算机增强成像。
DOI：
10.1073/pnas.84.16.6000
发表时间：
1987
影响因子：
11.1
作者：
Kirk,KL;Buku,A;Eggena,P
通讯作者：
Eggena,P
胞吞作用和胞吐作用：动物细胞中囊泡运输的当前概念。
DOI：
--
发表时间：
1984
期刊：
International Review of Cytology
影响因子：
--
作者：
M. Willingham;I. Pastan
通讯作者：
I. Pastan