Neuroendocrine control of lipid metabolism: lessons from C. elegans.

Neuroendocrine control of lipid metabolism: lessons from C. elegans.
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DOI:
10.1080/01677063.2020.1777116
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发表时间:
2020-09
影响因子:
1.9
通讯作者:
Srinivasan S
Srinivasan S
中科院分区:
医学4区
文献类型:
--
作者:
Srinivasan S

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This review article highlights our efforts to decode the role of the nervous system in regulating intestinal lipid metabolism in Caenorhabditis elegans. Capitalizing on the prescient and pioneering work of Sydney Brenner and John Sulston in establishing C. elegans as an immensely valuable model system, we have uncovered critical roles for oxygen sensing, population density sensing and food sensing in orchestrating the balance between storing lipids and utilizing them for energy in the intestine, the major organ for lipid metabolism in this model system. Our long-term goal is to reveal the integrative mechanisms and regulatory logic that underlies the complex relationship between genes, environment and internal state in the regulation of energy and whole-body physiology.
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